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Clinical features and prognostic factors for survival in patients with poorly differentiated thyroid carcinoma and comparison to the patients with the aggressive variants of papillary thyroid carcinoma

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Authors
Jung, Tae Sik; Kim, Tae Yong; Kim, Kyung Won; Oh, Young Lyun; Park, Do Joon; Cho, Bo Youn; Shong, Young Kee; Kim, Won Bae; Park, Young Joo; Jung, Jung Hwa; Chung, Jae Hoon
Issue Date
2007-03-24
Publisher
The Japan Endocrine Society
Citation
Endocr J. 2007 Apr;54(2):265-74. Epub 2007 Mar 20.
Keywords
AdolescentAdultAgedCarcinoma/*pathology/*physiopathology/secondaryCarcinoma, Papillary/*pathology/*physiopathology/secondary/surgeryDose-Response Relationship, RadiationFemaleHumansIodine Radioisotopes/therapeutic useLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRadiotherapy, AdjuvantRetrospective StudiesSeverity of Illness IndexSurvival AnalysisThyroid Neoplasms/*pathology/*physiopathology/surgeryThyroidectomy
Abstract
We performed this study to compare the clinicopathologic features and outcomes between the patients with poorly differentiated thyroid carcinoma (PDTC) and the patients with the aggressive variants of papillary thyroid carcinoma (PTC). To evaluate the prognostic factors for survival of the patients with PDTC, we selected 49 patients with PDTC and 23 patients with the aggressive variants of PTC from three hospitals during the recent 15 years. The five-year survival rate and clinicopathologic features of the patients with PDTC were not different from those of the patients with the aggressive variants of PTC. Univariate analysis revealed the significant poor prognostic factors for survival of the patients with PDTC and the aggressive variants of PTC as follows: 1) an age more than 45 years, 2) a tumor size larger than 4 cm, 3) the presence of tumor invasion to extrathyroidal tissue or the trachea, 4) the presence of cervical lymph node invasion, 5) the presence of distant metastasis, 6) the absence of high-dose radioactive iodine (RAI) therapy, and 7) TNM stage II, III and IV. Distant metastasis and high-dose RAI therapy were independent significant predictors for survival of the patients with PDTC and the aggressive variants of PTC on multivariate analysis. However, distant metastasis was the only independent significant predictors for survival of the patients with PDTC excluding patients with the aggressive variants of PTC.
ISSN
0918-8959 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17379963

http://hdl.handle.net/10371/46612
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College of Medicine/School of Medicine (의과대학/대학원)Molecular and Genomic Medicine (분자유전체의학전공)Journal Papers (저널논문_분자유전체의학전공)
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