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Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis

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Authors
Kim, Dong-Seok; Kim, So-Young; Park, Seo-Hyoung; Choi, Yeong-Gon; Kwon, Sun-Bang; Kim, Myo-Kyoung; Na, Jung-Im; Youn, Sang-Woong; Park, Kyoung-Chan
Issue Date
2005-12-06
Publisher
Pharmaceutical Society of Japan
Citation
Biol Pharm Bull. 2005 Dec;28(12):2216-9.
Keywords
AnimalsBlotting, WesternCell LineCell Survival/drug effectsDose-Response Relationship, DrugDown-Regulation/drug effectsDrug CombinationsDrug SynergismHumansHypopigmentation/chemically induced/metabolismMelanins/*antagonists & inhibitors/*biosynthesis/chemistryMiceMicrophthalmia-Associated Transcription Factor/antagonists &inhibitors/chemistry/drug effectsMonophenol Monooxygenase/*antagonists & inhibitors/drug effects/metabolismMonoterpenes/chemistry/pharmacologyResorcinols/chemistry/*pharmacologySignal Transduction/drug effectsSkin PigmentationTropolone/analogs & derivatives/chemistry/pharmacology
Abstract
In this study, we investigated the effects of 4-n-butylresorcinol on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Our results show that 4-n-butylresorcinol significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. Several reports have indicated that the activation of extracellular signal-regulated kinase (ERK) or of Akt reduces melanin synthesis via microphthalmia-associated transcription factor (MITF) down-regulation. Accordingly, we examined the effects of 4-n-butylresorcinol on the ERK and Akt signaling pathways. 4-n-Butylresorcinol did not induce ERK, Akt activation, or MITF degradation, and had no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. In contrast, 4-n-butylresorcinol strongly reduced tyrosinase activity in a cell-free system. Moreover, 4-n-butylresorcinol showed an additive effect in combination with hinokitiol, which reduces MITF expression. These results show that the hypopigmentary effect of 4-n-butylresorcinol results from its direct inhibition of tyrosinase.
ISSN
0918-6158 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16327152

http://hdl.handle.net/10371/46977
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College of Medicine/School of Medicine (의과대학/대학원)Molecular and Genomic Medicine (분자유전체의학전공)Journal Papers (저널논문_분자유전체의학전공)
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