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Efffects of pain inducing agents on voltage dependent calcium currents in the trigeminal ganglion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Kyungpyo | - |
dc.contributor.author | Kim, Seong-Ah | - |
dc.contributor.author | Kim, Youn-Bae | - |
dc.contributor.author | Kim, Joong-Soo | - |
dc.contributor.author | Lee, Jong-Heun | - |
dc.date.accessioned | 2010-02-01T06:00:25Z | - |
dc.date.available | 2010-02-01T06:00:25Z | - |
dc.date.issued | 2001-04 | - |
dc.identifier.citation | International Journal of Oral Biology 26:1-6, 2001. | en |
dc.identifier.issn | 1225-6390 | - |
dc.identifier.uri | https://hdl.handle.net/10371/47209 | - |
dc.description.abstract | Trigeminal ganglion (TG) neurons are primary sensory neurons involved in the transmission of orofacial sensation, including pain. It is known that intracellular free calcium concentration plays a critical role in neurotransmitter release. In the present study, we examined the effects of pain-inducing agents, bradykinin and histamine, on voltage dependent Ca^2+ current (I_Ca) and compared these with the effects of the analgesic agent, eugenol. I_Ca was measured using a whole-cell patch clamp method. Bradykinin (10μM) inhibited I_Ca in TG neurons. Maximum inward I_Ca was reduced by 26% by bradykinin compared with the controls (n=13, p<0.05). Decreased I_Ca induced by bradykinin did not recover to the prestimulus level after washing out bradykinin. In contrast, histamine (100μM) increased I_Ca by 25% compared with controls (n=7,p<0.05) in an irreversible manner. Eugenol (250μM), commonly used to produce analgesia in dental clinics, decreased I_Ca to 22.6% (n=9,p<0.05) and this effect on the I_Ca was reversible. although the effect of eugenol on the I_Ca was consistent, the effects of the two pain-inducing agents, bradykinin and histamine, were different. Our results suggest that the modulation of I_Ca in TG neurons is not a decisive factor underlying the pain mechanism evoked by pain-inducing agents. | en |
dc.language.iso | en | en |
dc.publisher | The Korean Academy of Oral Biology | en |
dc.subject | trigeminal ganglion(TG) | en |
dc.subject | voltage dependent Ca^2+ current(I_Ca) | en |
dc.subject | bradykinin | en |
dc.subject | histamine | en |
dc.subject | eugenol | en |
dc.title | Efffects of pain inducing agents on voltage dependent calcium currents in the trigeminal ganglion | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박경표 | - |
dc.contributor.AlternativeAuthor | 김성아 | - |
dc.contributor.AlternativeAuthor | 김연배 | - |
dc.contributor.AlternativeAuthor | 김종수 | - |
dc.contributor.AlternativeAuthor | 이종현 | - |
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