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Enhanced fibronectin-mediated cell adhesion of human osteoblast by fibroblast growth factor, FGF-2
Cited 32 time in
Web of Science
Cited 32 time in Scopus
- Authors
- Issue Date
- 2002-10
- Publisher
- Springer Verlag
- Citation
- Biotechnology Letters. 24: 1659-1663.
- Keywords
- cell adhesion ; extracellular matrix ; FGF-2 ; fibronectin ; signal transduction
- Abstract
- Using specific recombinant human fibronectin peptide (hFNIII9-10) that contains the binding site for integrin, we found that the fibroblast growth factor, FGF-2, enhances fibronectin-mediated adhesion in human osteoblast-like MG63 cells. The mechanism of the synergistic adhesion was due to the activation of extracellular-regulated kinase (ERK)-type MAPK upon interaction of integrin to hFNIII9-10 and its downstream activation of signaling pathways.
- ISSN
- 0141-5492
- Language
- English
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