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성견 치계줄기세포 및 골수줄기세포 특성에 관한 연구 : Investigation of postnatal stem cells from canine dental tissue and bone marrow
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 진민주 | - |
dc.contributor.author | 김영성 | - |
dc.contributor.author | 김수환 | - |
dc.contributor.author | 김경화 | - |
dc.contributor.author | 이철우 | - |
dc.contributor.author | 구기태 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 설양조 | - |
dc.contributor.author | 구영 | - |
dc.contributor.author | 류인철 | - |
dc.contributor.author | 정종평 | - |
dc.contributor.author | 이용무 | - |
dc.date.accessioned | 2010-02-01T09:48:40Z | - |
dc.date.available | 2010-02-01T09:48:40Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | 대한치주과학회지 2009;39:119-128. | en |
dc.identifier.issn | 0250-3352 | - |
dc.identifier.uri | https://hdl.handle.net/10371/47743 | - |
dc.description.abstract | Purpose: The aim of this study was to evaluate the stemness of cells from canine dental tissues and bone marrow. Methods: Canine periodontal ligament stem cells (PDLSC), alveolar bone stem cells (ABSC) and bone marrow stem cells(BMSC) were isolated and cultured. Cell differentiations (osteogenic, adipogenic and chondrogenic) and surface antigens (CD146, STRO-1, CD44, CD90, CD45, CD34) were evaluated in vitro. The cells were transplanted into the subcutaneous space of nude mice to assess capacity for ectopic bone formation at 8 weeks after implantation. Results: PDLSC, ABSC and BMSC differentiated into osteoblasts, adipocytes and chondrocytes under defined condition. The cells expressed the mesenchymal stem cell markers differently. When transplanted into athymic nude mice, these three kinds of cells with hydroxyapatite /- tricalcium phosphate (HA/TCP) carrier showed ectopic bone formation. Conclusions: This study demonstrated that canine dental stem cells have stemness like bone marrow stem cells. Transplantation of these cells might be used as a therapeutic approach for dental stem cell-mediated periodontal tissue regeneration. | en |
dc.description.sponsorship | 이 논문은 2008년도 과학기술부의 재원으로 한국과학재단의 지원을 받아 수행된 연구임(No. M10646010003-08N4601-00310). | en |
dc.language.iso | ko | en |
dc.publisher | 대한치주과학회 | en |
dc.subject | stem cells | en |
dc.subject | differentiation | en |
dc.subject | periodontal ligament | en |
dc.subject | regeneration | en |
dc.title | 성견 치계줄기세포 및 골수줄기세포 특성에 관한 연구 | en |
dc.title.alternative | Investigation of postnatal stem cells from canine dental tissue and bone marrow | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | Jhin, Min-Ju | - |
dc.contributor.AlternativeAuthor | Kim, Young-Sung | - |
dc.contributor.AlternativeAuthor | Kim, Su-Hwan | - |
dc.contributor.AlternativeAuthor | Kim, Kyoung-Hwa | - |
dc.contributor.AlternativeAuthor | Lee, Chul-Woo | - |
dc.contributor.AlternativeAuthor | Koo, Ki-Tae | - |
dc.contributor.AlternativeAuthor | Kim, Tae-Il | - |
dc.contributor.AlternativeAuthor | Seol, Yang-Jo | - |
dc.contributor.AlternativeAuthor | Ku, Young | - |
dc.contributor.AlternativeAuthor | Rhyu, In-Chul | - |
dc.contributor.AlternativeAuthor | Chung, Chong-Pyoung | - |
dc.contributor.AlternativeAuthor | Lee, Yong-Moo | - |
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