Effect of Prostaglandin E2 on Reflex Adrenal Catecholamine Secretion

Abstract

Prostaglandin E2 was administered peripherally and centrally to experimental dogs in order to demonstrate the effect of prostaglandin E2 on reflex adrenal secretion of catecholamines following hemorrhage in acutely anephric conditions. Diminished adrenal catecholamine secretion in anephric dogs was restored by peripheral infusion of prostaglandin E2 dose-dependently. Almost an identical response of adrenal secretion was observed by the peripheral and central infusions of prostaglandin E2, suggesting its effect is not selectively mediated by the central nervous system in contrast to angiotensin II. The action of prostaglandin E2 on the adrenal medulla in relation to the renin-angiotensin system appears to be systemic.