Electron Microscopic Features of Bone Marrow Cells in Korean Hemorrhagic Fever

Abstract

In eight male patients with Korean hemorrhagic fever, electron microscopic observations were made on the bone marrow cells during the early stage of the illness with the following results. 1) Several vacuoles were found in the cytoplasm of the erythrocytes and normoblasts. 2) Plasmacytoid cells rich in the rough endoplasmic reticulum, but not in its granules nor in mitochondria, were increased in number. 3) Phagocytic activities were demonstrated together with well-developed Golgi apparatus in the histiocytes and granulocytes. 4) Most megakaryocytes revealed abundant cytoplasm, the peripheral zone of which was actively producing platelets.