Cytoplasmic Estradiol and Progesterone Receptors in the Normal and Cancerous Tissues of the Uterine Cervix

Abstract

The changing patterns of estradiol receptorlfi-R) and progesterone receptor( PR) contents of the normal and cancerous tissues of the cervix were analyzed and the results were summarized as follows: L In the premenopausal group, EzR contents were significantly elevated in the secretory phase than in the proliferative phase but PR contents showed no difference. In the postmenopausal cervix, PR contents showed an apparent decrease than in the premenopause. And the positive rates of both receptors dropped significiantly in postmenopausal group compared to premenopause (p < 0.05). 2. The effect of gravidity and pairty of EzR and PR contents was not evident except significant decrease in EzR contents in the group of parity of more than 5. 3. Correlation between EzR and PR contents in the normal cervical tissues was significant in the premenopause but not in the postmenopause. 4. Cancerous changes from the normal cervical tissues had no effect on EzR and PR c 5. PR contents in the non-keratinizing cervical carcinoma were significantly higher than in the keratinizing type (p < 0.05) but change of EzR contents was not prominent. 6. The relationship of EzR and PR contents of cervical carcinoma with clinical stage and histopathologic parameters such as nuclear grade, mitotic rate, and lymphoid infiltration was not significant.