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Bayesian Feedback Method for Optimum Phenytoin Dosing : Phenytoin 용량적정화를 위한 Bayesian Feedback법
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Jae-Gook | - |
dc.contributor.author | Lee, Sun-Hee | - |
dc.contributor.author | Shin, Sang-Goo | - |
dc.contributor.author | Park, Chan-Woong | - |
dc.contributor.author | Rho, Jae-Kyu | - |
dc.contributor.author | Lee, Kwang-Woo | - |
dc.contributor.author | Myung, Ho-Jin | - |
dc.contributor.author | Kim, Jin-Qyu | - |
dc.date.accessioned | 2009-07-14T14:47:35Z | - |
dc.date.available | 2009-07-14T14:47:35Z | - |
dc.date.issued | 1989-06 | - |
dc.identifier.citation | Seoul J Med, Vol.30 No.2, pp. 105-111 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/5541 | - |
dc.description.abstract | The accuracy of Bayesian feedback method for predicting phenytoin dosage
was assessed and compared to conventional predictive methods such as the Richens & Dunlop method and Ludden method from 57 patients who took phenytoin for the treatment of grandmal epilepsy, For the comparison of absolute predictability of each method, correlation coefficient between predicted and actual dosage, mean error (ME) and root mean squared error (RMSE) were calculated. For a single data pair, the Bayesian method showed a higher correlation coefficient (0.915) and' less ME & RMSE values( -2.0'1"0 & 8.8'X)) than the Richens & Dunlop methood, and there was a staitistically significant difference between these two methods (p < 0,05). For multiple dat pairs, the Bayesian method also showed a higher correlation coefficient (0,93) and less ME & RMSE values (0.69% & 7.2<1'0), though there was no significant difference. It is suggested that the Bayesian method has better predictability and can be used conveniently even with single Cpss-dosc data pair for optimum phenytoin dosage prediction. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Phenytoin | - |
dc.subject | Dosage prediction | - |
dc.subject | Bayesian method | - |
dc.subject | Ludden method | - |
dc.subject | Richens & Dunlop method | - |
dc.title | Bayesian Feedback Method for Optimum Phenytoin Dosing | - |
dc.title.alternative | Phenytoin 용량적정화를 위한 Bayesian Feedback법 | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 신재국 | - |
dc.contributor.AlternativeAuthor | 이선희 | - |
dc.contributor.AlternativeAuthor | 신상구 | - |
dc.contributor.AlternativeAuthor | 박찬웅 | - |
dc.contributor.AlternativeAuthor | 노재규 | - |
dc.contributor.AlternativeAuthor | 이광우 | - |
dc.contributor.AlternativeAuthor | 명호진 | - |
dc.contributor.AlternativeAuthor | 김진규 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 111 | - |
dc.citation.number | 2 | - |
dc.citation.pages | 105-111 | - |
dc.citation.startpage | 105 | - |
dc.citation.volume | 30 | - |
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