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Detection of Hantaan Viral Antigens in Renal Tissues from a Patient with Korean Hemorrhagic Fever in Convalescent Phase

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Authors
Lim, Chun Soo; Yang, Won Seok; Kim, Yon Su; Jung, Yoon Chul; Ahn, Curie; Han, Jin Suk; Kim, Suhnggwon; Lee, Jung Sang
Issue Date
1993-09
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.34 No.3, pp. 229-235
Keywords
Korean hemorrhagic feverHantaan virusEnvelope glycoproteinlmmunohistochemistryMonoclonal antibodies
Abstract
A case of a patient with Korean hemorrhagic fever (KHF) who
showed typical clinical manifestations is described for the purpose of reporting
the detection of Hantaan viral antigens in renal tissues. The pathophysiologic
mechanisms of renal damage are not well known, and several mechanisms including
direct renal injury by the virus itself have been proposed to explain the renal
lesions and the clinical manifestations. We detected Hantaan viral antigens in
renal tissues from a KHF patient in the convalescent phase by the immunohistochemical
method using the monoclonal antibodies to Hantaan viral envelope glycoproteins
(G1, G2). The immunostainings demonstrated Hantaan viral antigens
in the renal tubular epithelial cells, the intraluminal desquamated tubular cells,
the infiltrated cells in the interstitium, and the capillary endothelial cells in the
interstitium and glomeruli. The presence of viral antigens in renal tissues may
support the hypothesis that direct renal injury by the virus is one of the pathophysiologic
mechanisms of renal damage in KHF
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/5571
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 34 No.3 (1993)
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