ChiIdhood GIioblastoma Multiforme Mimicking BasaI Meningitis -Report of An Autopsy Case-

Cited 0 time in webofscience Cited 0 time in scopus
Song, Sang Yong; Chi, Je G.
Issue Date
Seoul National University College of Medicine
Seoul J Med 1993;34(1):63-67
Glioblastoma multiformeChildhoodThalamusHypothalamusBrainstemMeningitisLeptomeningeal spread
Glioblastoma multiforme is a highly malignant neuroglial tumor
rarely reported in children with several differences compared to the adult tumor.
Its clinical diagnosis is sometimes difficult because most children do not have an
antecedant history to herald the development of the tumor. We report a case of
glioblastoma multiforme in a child that presented clinically and radiologically as a
tuberculous basal meningitis, and turned out to be a glioblastoma multiforme
involving the thalamus, hypothalamus and brainstem, and spreading massively
through the leptomeningeal and ventricular spaces. A 6-year-old girl presented
with non-projectile vomiting and mild fever on October 1990. Over the ensuing 6
months she was found to have hydrocephalus and blurring of vision. She was
treated for possible tuberculous meningitis without any improvement. Repeated
CSF smears, cultures, cytology and brain CT did not provide any clue to a
specific diagnosis. She remained stationary until January 23, 1992 when she
elappsed into coma at home and died after supportive management for 7 days.
Postmortem examination showed widespread gray white coating or nodules over
the cerebellar and cerebral convexities as well as the brain base. Serial sections
revealed that the main lesion was located in the thalamus, hypothalamus, and
brainstem. Microscopically, it was a glioblastoma multiforme consisting
predominantly of anaplastic spindle cells.
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 34 No.1 (1993)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.