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Comparative Study for the Differentiation of Allergic and Irritant Contact Dermatitis in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Jin Ho | - |
dc.contributor.author | Kim, Kyu Han | - |
dc.contributor.author | Koh, Woo Seok | - |
dc.contributor.author | Park, Kyoung Chan | - |
dc.date.accessioned | 2009-07-14T23:04:59Z | - |
dc.date.available | 2009-07-14T23:04:59Z | - |
dc.date.issued | 1993-03 | - |
dc.identifier.citation | Seoul J Med, Vol.34 No.1, pp. 49-54 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/5592 | - |
dc.description.abstract | Our study was performed to compare the differences between
allergic and irritant contact dermatitis in BALB/c mice. Allergic reaction was induced by a sensitizing regimen of 2,4-dinitro-l-fluorobenzene (DNFB) and irritant reaction by 10% sodium lauryl sulfate (SLS). The following differences were noted: 1) the mice with irritant reaction showed an earlier peak of ear swelling, 2) increasing number of Langerhans cells (LCs) in allergic reaction but decreasing number of LCs in irritant reaction was observed at 48 hr after challenge of DNFB or SLS, and 3) induction of Ia (+) keratinocytes was found only in allergic reaction. It was suggested that Ia (+) keratinocytes play an active role in the mechanism of allergic contact dermatitis. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Allergic and irritant contact dermatitis | - |
dc.subject | BALB/c mice | - |
dc.subject | Langerhans cells | - |
dc.subject | Ear swelling | - |
dc.subject | la (+) keratinocytes | - |
dc.title | Comparative Study for the Differentiation of Allergic and Irritant Contact Dermatitis in Mice | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.contributor.AlternativeAuthor | 김규한 | - |
dc.contributor.AlternativeAuthor | 고우석 | - |
dc.contributor.AlternativeAuthor | 박경찬 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 54 | - |
dc.citation.number | 1 | - |
dc.citation.pages | 49-54 | - |
dc.citation.startpage | 49 | - |
dc.citation.volume | 34 | - |
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