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Partial Ureteral Obstruction: A New Experimental Model In Rats

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Authors
Kim, Kwang Myung; Kim, Dae Kyung; Choi, Hwang
Issue Date
1993-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.34 No.1, pp. 55-61
Keywords
Partial ureteral obstructionExperimental modelRat
Abstract
Partial ureteral obstruction in rats has been usually created by
implanting the mid ureter into the psoas muscle. However, this method does not
allow us to choose the obstruction site or the degree of obstruction. On the other
hand, the extrinsic stent insertion method needs highly sophisticated operation
skill. Hence, we tried to make a new experimental model using a bisected
segment of 8 F feeding tube. We made various sizes of central holes with needles
in that piece and then placed the left ureter into the hole through a J-shaped
incised route. The occurrence of partial ureteral obstruction was checked by
excretory urogram, direct injection of indigocarmine into the upper dilated ureter
and histopathological examination. Actually, partial ureteral obstruction occurred
in 67% of rats in the 236 group (n=6) and in 57% in the 216 group (n=7) in a
week. Complete obstruction occurred in 33% in the 236 group and in 29% in the
216 group. The control group (n=6) in which an 186 needle (greater than ureter
diameter) was used showed 33% of partial obstruction but there was no case of
complete obstruction.These data show that our new experimental model inducing
partial ureter obstruction in rats has reliability, variability and simplicity.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/5593
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 34 No.1 (1993)
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