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Chemotherapy of Human Colon Cancer Transplanted in Nude Mouse
누드 마우스에 이식된 인체대장암에 대한 화학요법

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Authors
Jung, Sung Eun; Park, Jae-Gahb; Kim, Jin-Pok
Issue Date
1987-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1987;28(1):28-35
Keywords
ChemotherapyHuman colon cancer transplantedNude mouse
Abstract
Human colon carcinomas, transplantable in BALB/c nude mice, designated as
SCN-l, SCN-2 and SCN-4, were serially passed for 8, 12 and 8 generations respectively. A
piece of each tumor excised to 2 mm in diameter was inoculated subcutaneously on the back
of nude mice. Experimental chemotherapies with a single drug, adriamycin, mitomycin C or
5-fluorouracil were started when the tumors reached 5-6 mm in diameter. The results showed
that mitomycin C and 5-fluorouracil significantly suppressed the growth of colon cancer. The
histologic features of transplanted tumor were similar to those of the original tumors.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/5685
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.1 (1987)
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