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Lysophosphatidylserine regulates blood glucose by enhancing glucose transport in myotubes and adipocytes

Cited 12 time in Web of Science Cited 11 time in Scopus
Authors
Yea, Kyungmoo; Kim, Jaeyoon; Lim, Seyoung; Kwon, Taewan; Park, Ho Seon; Park, Kyong Soo; Suh, Pann-Ghill; Ryu, Sung Ho
Issue Date
2008-12-10
Publisher
Elsevier
Citation
Biochem Biophys Res Commun. 2009 Jan 23;378(4):783-8. Epub 2008 Dec 6.
Keywords
1-Phosphatidylinositol 3-Kinase/metabolism3T3 CellsAdipocytes/drug effects/*metabolismAnimalsBlood Glucose/drug effects/*metabolismCell LineDiabetes Mellitus, Experimental/metabolismDiabetes Mellitus, Type 1/metabolismDiabetes Mellitus, Type 2/metabolismHumansLysophospholipids/pharmacology/*physiologyMiceMice, Inbred StrainsMuscle Fibers, Skeletal/drug effects/*metabolismRats
Abstract
Lysophosphatidylserine (LPS) is known to have diverse cellular effects, but although LPS is present in many biological fluids, its in vivo effects have not been elucidated. In the present study, we investigated the effects of LPS on glucose metabolism in vivo, and how skeletal muscle cells respond to LPS stimulation. LPS enhanced glucose uptake in a dose- and time-dependent manner in L6 GLUT4myc myotubes, and this effect of LPS on glucose uptake was mediated by a Galpha(i) and PI 3-kinase dependent signal pathway. LPS increased the level of GLUT4 on the cell surface of L6 GLUT4myc myotubes, and enhanced glucose uptake in 3T3-L1 adipocytes. In line with its cellular functions, LPS lowered blood glucose levels in normal mice, while leaving insulin secretion unaffected. LPS also had a glucose-lowering effect in STZ-treated type 1 diabetic mice and in obese db/db type 2 diabetic mice. This study shows that LPS-stimulated glucose transport both in skeletal muscle cells and adipocytes, and significantly lowered blood glucose levels both in type 1 and 2 diabetic mice. Our results suggest that LPS is involved in the regulation of glucose homeostasis in skeletal muscle and adipose tissue.
ISSN
1090-2104 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19063864

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBK-4V3565W-B-9&_cdi=6713&_user=168665&_orig=search&_coverDate=01%2F23%2F2009&_sk=996219995&view=c&wchp=dGLzVtb-zSkzS&md5=2b3547b912d22add9eabcd8504d3a8ee&ie=/sdarticle.pdf

http://hdl.handle.net/10371/58494
DOI
https://doi.org/10.1016/j.bbrc.2008.11.122
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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