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EGFR gene copy number in adenocarcinoma of the lung by FISH analysis: investigation of significantly related factors on CT, FDG-PET, and histopathology
DC Field | Value | Language |
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dc.contributor.author | Park, Eun-Ah | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Kim, Young Tae | - |
dc.contributor.author | Kang, Chang Hyun | - |
dc.contributor.author | Kang, Keon Wook | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Goo, Jin Mo | - |
dc.contributor.author | Lee, Chang Hyun | - |
dc.contributor.author | Park, Chang Min | - |
dc.date.accessioned | 2010-03-24T06:48:30Z | - |
dc.date.available | 2010-03-24T06:48:30Z | - |
dc.date.issued | 2008-09-30 | - |
dc.identifier.citation | Lung Cancer 2009;64:179–186 | en |
dc.identifier.issn | 1872-8332 (Electronic) | - |
dc.identifier.uri | https://hdl.handle.net/10371/61887 | - |
dc.description.abstract | It has been suggested that a high EGFR gene copy number may be an indicator of good response to EGFR tyrosine kinase inhibitor therapy and a marker of poor prognosis in NSCLC. However, imaging features related to EGFR gene copy number status in adenocarcinoma are still unknown. We therefore retrospectively analyzed CT, FDG-PET, and histopathologic slides of surgical resected lung adenocarcinoma in 132 patients. Tumor characteristics on preoperative chest-CT, such as, GGO proportions, tumor diameters, and cavitation; FDG-PET SUV(max); and histopathologically determined differentiation degrees and tumor subtypes were evaluated. EGFR gene copy number status was categorized as FISH-positive or -negative. FISH-positivity was found in 53 patients (40.2%) and was significantly more frequent in tumors with a SUV(max)>7.0 (P=0.007). Furthermore, FISH-negativity was found to be more frequent in tumors with a GGO>50% (P=0.023) and diameter <15.5mm (P=0.006) on CT, or a well-differentiated histopathology (P=0.002). Moreover, the frequency of FISH-positivity increased as SUV(max) increased (P=0.0008) and as the proportion of GGO decreased (P=0.01). SUV(max)>7.0 was an independent predictor of FISH-positive results (odds ratio, 3.941; 95% CI, 1.691-9.182; P=0.01). In conclusion, a high SUV(max) on FDG-PET was significantly related to FISH-positive results. A high proportion of GGO, small tumor diameter on CT, and a well-differentiated histopathology were more frequent in FISH-negative adenocarcinomas. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adenocarcinoma/*genetics/*radiography/*radionuclide imaging | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Fluorodeoxyglucose F18/diagnostic use | en |
dc.subject | Gene Dosage | en |
dc.subject | Humans | en |
dc.subject | Image Interpretation, Computer-Assisted | en |
dc.subject | In Situ Hybridization, Fluorescence | en |
dc.subject | Lung Neoplasms/*genetics/*radiography/*radionuclide imaging | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Positron-Emission Tomography | en |
dc.subject | Radiopharmaceuticals/diagnostic use | en |
dc.subject | Receptor, Epidermal Growth Factor/*genetics | en |
dc.subject | Retrospective Studies | en |
dc.subject | Tomography, X-Ray Computed | en |
dc.title | EGFR gene copy number in adenocarcinoma of the lung by FISH analysis: investigation of significantly related factors on CT, FDG-PET, and histopathology | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박은아 | - |
dc.contributor.AlternativeAuthor | 이현주 | - |
dc.contributor.AlternativeAuthor | 김영태 | - |
dc.contributor.AlternativeAuthor | 강창현 | - |
dc.contributor.AlternativeAuthor | 강건욱 | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 구진모 | - |
dc.contributor.AlternativeAuthor | 이창현 | - |
dc.contributor.AlternativeAuthor | 박창민 | - |
dc.identifier.doi | 10.1016/j.lungcan.2008.08.003 | - |
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