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Dibenzocyclooctadiene Lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, So Ra | - |
dc.contributor.author | Lee, Mi Kyeong | - |
dc.contributor.author | Koo, Kyung Ah | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Sung, Sang Hyun | - |
dc.contributor.author | Lee, Na Gyong | - |
dc.contributor.author | Markelonis, George J. | - |
dc.contributor.author | Oh, Tae H. | - |
dc.contributor.author | Yang, Jae Ho | - |
dc.contributor.author | Kim, Young Choong | - |
dc.date.accessioned | 2010-03-26T07:18:58Z | - |
dc.date.available | 2010-03-26T07:18:58Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Journal of Neuroscience Research 76:397–405 | en |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.uri | https://hdl.handle.net/10371/62031 | - |
dc.description.abstract | A methanolic extract of dried Schisandra fruit (Schisandra
chinensis Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells. Five dibenzocyclooctadiene lignans (deoxyschisandrin, gomisin N, gomisin A, schisandrin, and wuweizisu C) were isolated from the methanolic extract; their protective effects against glutamate-induced neurotoxicity were then evaluated. Among the five lignans, deoxyschisandrin, gomisin N, and wuweizisu C significantly attenuated glutamate-induced neurotoxicity as measured by 1) an inhibition in the increase of intracellular [Ca2 ]; 2) an improvement in the glutathione defense system, the level of glutathione, and the activity of glutathione peroxidase; and 3) an inhibition in the formation of cellular peroxide. These results suggest that dibenzocyclooctadiene lignans from Schisandra chinensis may possess therapeutic potential against oxidative neuronal damage induced by excitotoxin. | en |
dc.description.sponsorship | Contract grant sponsor: National Center for Complementary and Alternative
Medicine at the National Institutes of Health; Contract grant number: RO1- AT00106-05; Contract grant sponsor: Brain Korea 21 project in 2003. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | dibenzocyclooctadiene lignans | en |
dc.subject | excitotoxic cell damage | en |
dc.subject | glutathione defense system | en |
dc.subject | neuroprotective activity | en |
dc.subject | Schisandra chinensis | en |
dc.title | Dibenzocyclooctadiene Lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김소라 | - |
dc.contributor.AlternativeAuthor | 이미경 | - |
dc.contributor.AlternativeAuthor | 구경아 | - |
dc.contributor.AlternativeAuthor | 김승현 | - |
dc.contributor.AlternativeAuthor | 성상현 | - |
dc.contributor.AlternativeAuthor | 이나경 | - |
dc.contributor.AlternativeAuthor | 양재호 | - |
dc.contributor.AlternativeAuthor | 김영중 | - |
dc.identifier.doi | 10.1002/jnr.20089 | - |
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