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Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhou, Zhen | - |
dc.contributor.author | Pollok, Karen E | - |
dc.contributor.author | Kim, Kack K | - |
dc.contributor.author | Kim, Young-June | - |
dc.contributor.author | Kwon, Byoung S | - |
dc.date.accessioned | 2010-03-31T05:52:48Z | - |
dc.date.available | 2010-03-31T05:52:48Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Immunology Letters. 41, 177-184. | en |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | https://hdl.handle.net/10371/62209 | - |
dc.description.abstract | The 4-1BB antigen has been recently demonstrated to be a 30 kDa inducible T-cell antigen and is expressed on the cell surface of activated splenic T cells and thymocytes. This novel T-cell antigen also associates physically with the T cell-specific protein tyrosine kinase, p56lck. We show here that the inducible T-cell antigen 4-1BB is expressed on activated intestinal intra-epithelial T lymphocytes (IEL). After activation, or in the presence of IL-2, the activated IELs showed higher levels of 4-1BB. Functional studies revealed that the activated IELs triggered with anti-4-1BB monoclonal antibody could enhance the level of IEL cytotoxicity against anti-CD3-secreting hybridoma cells. Cross-linking of anti-4-1BB antibody also enhanced the proliferation of IELs. These results suggest that the inducible antigen 4-1BB has broad biological functions which not only play a role in activated splenic T cells and thymocytes but also in the mucosal immune system. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | 4-1BB | en |
dc.subject | Intra-epithelial lymphocyte | en |
dc.subject | phenotype/function | en |
dc.title | Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김영준 | - |
dc.identifier.doi | 10.1016/0615-2478(94)90129-5 | - |
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