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N-terminal pro-B-type natriuretic peptide as a predictor of repeat coronary revascularization
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sir, Jung-Ju | - |
dc.contributor.author | Chung, Woo-Young | - |
dc.contributor.author | Hwang, Seok-Jae | - |
dc.contributor.author | Kang, Hyun-Jae | - |
dc.contributor.author | Cho, Young-Seok | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Chae, In-Ho | - |
dc.contributor.author | Choi, Dong-Ju | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.contributor.author | Sohn, Dae-Won | - |
dc.contributor.author | Kim, Cheol-Ho | - |
dc.contributor.author | Oh, Byung-Hee | - |
dc.contributor.author | Park, Young-Bae | - |
dc.contributor.author | Choi, Yun-Shik | - |
dc.date.accessioned | 2010-03-31T06:05:20Z | - |
dc.date.available | 2010-03-31T06:05:20Z | - |
dc.date.issued | 2007-06-05 | - |
dc.identifier.citation | Int J Cardiol. 2008 ;126(3):322-32. | en |
dc.identifier.issn | 1874-1754 (Electronic) | - |
dc.identifier.uri | https://hdl.handle.net/10371/62213 | - |
dc.description.abstract | BACKGROUND: Recent studies suggest that natriuretic peptides are potential biomarkers for myocardial ischemia. However, little is known about the value of NT-proBNP as a predictor of repeat revascularization (RR) at follow-up angiography in patients with normal LV systolic function. METHODS: We collected and analyzed the clinical and angiographic data from 445 consecutive patients (62.5+/-10.1 years; 73% males) who showed normal LV systolic function and no regional wall motion abnormalities on transthoracic echocardiogram performed at baseline and follow-up angiography. RESULTS: Overall, NT-proBNP level on admission for follow-up angiography was significantly higher in patients with RR (n=55) than those without RR (n=390) [92.4 (47.5-178.5) pg/ml vs. 54.8 (30.6-93.1) pg/ml, P<0.001]. In asymptomatic patients, NT-proBNP did not show significant difference between patients with RR and those without RR (P=0.42). An elevated NT-proBNP level, especially in symptomatic patients (n=77) (>87.5 pg/ml as an optimal cut off value) was a strong independent predictor for RR at follow-up angiography (OR, 12.3; 95% CI, 3.25-46.2; P=0.001). NT-proBNP (>122.9 pg/ml) showed high specificity (85.9%) and negative predictive value (91.0%) for predicting RR in overall patients. However, NT-proBNP (>97.0 pg/ml) showed low sensitivity (49.1%) and positive predictive value (23.5%). The areas under the receiver operator characteristic (ROC) curve in predicting RR in overall patients and symptomatic patients were 0.648 (95% CI; 0.564-0.732, P<0.001) and 0.768 (95% CI; 0.653-0.884, P<0.001), respectively. CONCLUSION: Our data show that NT-proBNP level at follow-up is a strong independent predictor for RR especially in symptomatic patients. Although routine measurement may be not useful for predict RR, NT-proBNP may help to identify patients with low risk of repeat revascularization. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Age Factors | en |
dc.subject | Aged | en |
dc.subject | Analysis of Variance | en |
dc.subject | Angioplasty, Transluminal, Percutaneous Coronary/*methods | en |
dc.subject | Biological Markers/blood | en |
dc.subject | Cohort Studies | en |
dc.subject | Coronary Angiography | en |
dc.subject | Coronary Disease/*diagnosis/mortality/*therapy | en |
dc.subject | Echocardiography, Transesophageal | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Myocardial Ischemia/diagnosis/mortality/therapy | en |
dc.subject | Natriuretic Peptide, Brain/*blood | en |
dc.subject | Peptide Fragments/*blood | en |
dc.subject | Predictive Value of Tests | en |
dc.subject | Prognosis | en |
dc.subject | ROC Curve | en |
dc.subject | Retreatment | en |
dc.subject | Risk Assessment | en |
dc.subject | Sensitivity and Specificity | en |
dc.subject | Severity of Illness Index | en |
dc.subject | Sex Factors | en |
dc.subject | Tomography, Emission-Computed, Single-Photon | en |
dc.subject | Treatment Outcome | en |
dc.subject | Ventricular Remodeling/*physiology | en |
dc.title | N-terminal pro-B-type natriuretic peptide as a predictor of repeat coronary revascularization | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 서정주 | - |
dc.contributor.AlternativeAuthor | 정우영 | - |
dc.contributor.AlternativeAuthor | 황석재 | - |
dc.contributor.AlternativeAuthor | 강현재 | - |
dc.contributor.AlternativeAuthor | 조영석 | - |
dc.contributor.AlternativeAuthor | 구본권 | - |
dc.contributor.AlternativeAuthor | 채인호 | - |
dc.contributor.AlternativeAuthor | 최동주 | - |
dc.contributor.AlternativeAuthor | 김효수 | - |
dc.contributor.AlternativeAuthor | 손대원 | - |
dc.contributor.AlternativeAuthor | 김철호 | - |
dc.contributor.AlternativeAuthor | 오병희 | - |
dc.contributor.AlternativeAuthor | 박영배 | - |
dc.contributor.AlternativeAuthor | 최윤식 | - |
dc.identifier.doi | 10.1016/j.ijcard.2007.04.007 | - |
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