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Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis

Cited 42 time in Web of Science Cited 47 time in Scopus
Authors
Song, Kyoung-Ho; Jeon, Jae Hyun; Park, Wan Beom; Kim, Sung-Han; Park, Kyoung Un; Kim, Nam Joong; Oh, Myoung-don; Kim, Hong Bin; Choe, Kang Won
Issue Date
2008-12-17
Publisher
Elsevier
Citation
Diagn Microbiol Infect Dis. 2009;63(2):182-7.
Keywords
AdolescentAdultAgedAged, 80 and overEnzyme-Linked Immunosorbent Assay/*methodsFemaleHumansInterferon-gamma/*bloodMaleMiddle AgedMycobacterium tuberculosis/genetics/isolation & purificationPolymerase Chain ReactionPredictive Value of TestsReagent Kits, DiagnosticSensitivity and SpecificityTuberculosis/*diagnosis/*immunology/microbiologyTuberculosis, Lymph Node/diagnosis/immunology/microbiology
Abstract
The whole-blood interferon-gamma enzyme-linked immunosorbent assay (QuantiFERON-TB Gold [QFT-G]; Cellestis, Carnegie, Australia) has been studied mainly for diagnosing active pulmonary tuberculosis (TB) or latent TB. We prospectively evaluated its diagnostic usefulness in patients suspected with extrapulmonary TB (EP-TB). Of the 100 adult patients with suspected EP-TB, 43 were classified as "confirmed" EP-TB and 5 as "probable" EP-TB. Of the 48 with EP-TB, 27 (56%) were diagnosed with TB lymphadenitis and 11 (17%) with skeletal TB. The overall sensitivity and specificity of the assay were 69% (95% confidence interval [CI(95)], 53-81%) and 82% (CI(95), 69-91%), respectively. Among 44 patients presented with cervical lymphadenopathy, the QFT-G assay showed 86% (CI(95), 64-97%) sensitivity and 87% (CI(95), 66-97%) specificity, whereas in 28 with skeletal involvement, the sensitivity and specificity of the assay were 45% (CI(95), 17-77%) and 81% (CI(95), 54-96%), respectively. These suboptimal diagnostic performances suggest that the QFT-G assay alone is not sufficient for the diagnosis of EP-TB.
ISSN
1879-0070 (Electronic)
Language
English
URI
http://hdl.handle.net/10371/62215
DOI
https://doi.org/10.1016/j.diagmicrobio.2008.10.013
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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