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Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis
Cited 44 time in
Web of Science
Cited 49 time in Scopus
- Authors
- Issue Date
- 2008-12-17
- Publisher
- Elsevier
- Citation
- Diagn Microbiol Infect Dis. 2009;63(2):182-7.
- Keywords
- Adolescent ; Adult ; Aged ; Aged, 80 and over ; Enzyme-Linked Immunosorbent Assay/*methods ; Female ; Humans ; Interferon-gamma/*blood ; Male ; Middle Aged ; Mycobacterium tuberculosis/genetics/isolation & purification ; Polymerase Chain Reaction ; Predictive Value of Tests ; Reagent Kits, Diagnostic ; Sensitivity and Specificity ; Tuberculosis/*diagnosis/*immunology/microbiology ; Tuberculosis, Lymph Node/diagnosis/immunology/microbiology
- Abstract
- The whole-blood interferon-gamma enzyme-linked immunosorbent assay (QuantiFERON-TB Gold [QFT-G]; Cellestis, Carnegie, Australia) has been studied mainly for diagnosing active pulmonary tuberculosis (TB) or latent TB. We prospectively evaluated its diagnostic usefulness in patients suspected with extrapulmonary TB (EP-TB). Of the 100 adult patients with suspected EP-TB, 43 were classified as "confirmed" EP-TB and 5 as "probable" EP-TB. Of the 48 with EP-TB, 27 (56%) were diagnosed with TB lymphadenitis and 11 (17%) with skeletal TB. The overall sensitivity and specificity of the assay were 69% (95% confidence interval [CI(95)], 53-81%) and 82% (CI(95), 69-91%), respectively. Among 44 patients presented with cervical lymphadenopathy, the QFT-G assay showed 86% (CI(95), 64-97%) sensitivity and 87% (CI(95), 66-97%) specificity, whereas in 28 with skeletal involvement, the sensitivity and specificity of the assay were 45% (CI(95), 17-77%) and 81% (CI(95), 54-96%), respectively. These suboptimal diagnostic performances suggest that the QFT-G assay alone is not sufficient for the diagnosis of EP-TB.
- ISSN
- 1879-0070 (Electronic)
- Language
- English
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