Publications
Detailed Information
Expression and functional dcharacterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Joo-Cheol | - |
dc.contributor.author | Yoon, Jung-Hoon | - |
dc.contributor.author | Kim, Youn-Bae | - |
dc.contributor.author | Kim, Myong-Soo | - |
dc.contributor.author | Kook, Joong-Ki | - |
dc.contributor.author | Jung, Hae-Man | - |
dc.contributor.author | Kim, Saeng-Gon | - |
dc.contributor.author | Yoo, Hoon | - |
dc.contributor.author | Ko, Yeong-Mu | - |
dc.contributor.author | Lee, Sang-Ho | - |
dc.contributor.author | Kim, Bong-Young | - |
dc.contributor.author | Chun, Hong-Sung | - |
dc.contributor.author | Kanai, Yoshikatsu | - |
dc.contributor.author | Endou, Hitoshi | - |
dc.contributor.author | Kim, Do-Kyung | - |
dc.date.accessioned | 2010-03-31T07:49:22Z | - |
dc.date.available | 2010-03-31T07:49:22Z | - |
dc.date.issued | 2004-03 | - |
dc.identifier.citation | CANCER LETTERS, 205 (2004).,215-226. | en |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://hdl.handle.net/10371/62241 | - |
dc.description.abstract | We have examined the expression and function of system amino acid transporter in KB human oral epidermoid carcinoma cells. The KB cells express -type amino acid transporter 1 (LAT1) in plasma membrane, but not -type amino acid transporter 2 (LAT2). The [14C]-leucine uptake by KB cells is inhibited by system selective inhibitor BCH. The majority of [14C]-leucine uptake is, therefore, mediated by LAT1. These results suggest that the transport of neutral amino acids including several essential amino acids into the KB cells mediated by LAT1 and the specific inhibition of LAT1 in oral cancer cells will be a new rationale for anti-cancer therapy | en |
dc.description.sponsorship | This work was supported by grant No.(R01-2002-000-00165-0 (2002)) from the Basic Research Program of the Korea Science and Engineering Foundation. Anti-LAT1, anti-LAT2 and anti-4F2hc polyclonal antibodies were supplied by Kumamoto Immunochemcial Laboratory, Transgenic., Kumamoto, Japan. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | author keywords | en |
dc.subject | type amino acid transporter | en |
dc.subject | KB human oral epidermoid carcinima cells | en |
dc.subject | essential amino acids | en |
dc.subject | anti-cancer therapy | en |
dc.title | Expression and functional dcharacterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박주철 | - |
dc.contributor.AlternativeAuthor | 윤정훈 | - |
dc.contributor.AlternativeAuthor | 김윤배 | - |
dc.contributor.AlternativeAuthor | 김명수 | - |
dc.contributor.AlternativeAuthor | 국중기 | - |
dc.contributor.AlternativeAuthor | 정해만 | - |
dc.contributor.AlternativeAuthor | 김생곤 | - |
dc.contributor.AlternativeAuthor | 유훈 | - |
dc.contributor.AlternativeAuthor | 고영무 | - |
dc.contributor.AlternativeAuthor | 이상호 | - |
dc.contributor.AlternativeAuthor | 김봉영 | - |
dc.contributor.AlternativeAuthor | 천홍성 | - |
dc.contributor.AlternativeAuthor | 김도경 | - |
dc.identifier.doi | 10.1016/j.canlet.2003.10.009 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.