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"Expression of membrane type I-Matrix metalloproteinase in oral squamous cell carcinoma.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Sam-Pyo | - |
dc.contributor.author | Myoung, Hoon | - |
dc.contributor.author | Kim, Myung-Jin | - |
dc.contributor.author | Hong, Seong-Doo | - |
dc.contributor.author | Lee, Jae-Il | - |
dc.contributor.author | Lim, Chang-Yun | - |
dc.date.accessioned | 2010-04-01T05:06:05Z | - |
dc.date.available | 2010-04-01T05:06:05Z | - |
dc.date.issued | 2002-11 | - |
dc.identifier.citation | Cancer Letters 185 (2002) 201-209. | en |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://hdl.handle.net/10371/62311 | - |
dc.description.abstract | A local invasion and lymph node metastasis (LNM) of an oral squamous cell carcinoma (OSCC) has a poor prognosis, and involves the degradation of the extracellular matrix mediated by multiple proteolytic enzymes including membrane type I-matrix metalloproteinase (MT1-MMP). This study aimed to determine the role of MT1-MMP in OSCC, to evaluate the immunohistochemical expression of MT1-MMP with regard to the invasiveness and LNM of the OSCC, and to evaluate the major source of MT1-MMP mRNA and its protein using immunohistochemistry and in situ hybridization. MT1-MMP expression was examined in 46 OSCCs via immunohistochemistry and non-radioisotope in situ hybridization. The relationship between MT1-MMP expression and LNM, as well as the histological invasiveness, was statistically analyzed. The results showed that whereas 12 out of the 18 OSCCs (66.7%) with LNM showed moderate to strong MT1-MMP expression, only nine of the 28 OSCCs (32.1%) without LNM expressed MT1-MMP strongly. MT1-MMP expression was significantly higher with regard to LNM (P=0.022). As the invasion grade became stronger (from grade a to grade d), MT1-MMP was significantly more strongly expressed (P=0.033). These results suggest that MT1-MMP is primarily secreted in the OSCC cells and is involved in the invasiveness of the OSCC and LNM. Moreover, MT1-MMP combined with other markers may be used to predict the metastatic potential of an OSCC. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | membrane type1-matrix | en |
dc.subject | metalloproteinase | en |
dc.subject | oral squamous cell carcinoma | en |
dc.subject | lymph node metastasis | en |
dc.subject | invasion | en |
dc.title | "Expression of membrane type I-Matrix metalloproteinase in oral squamous cell carcinoma. | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 홍삼표 | - |
dc.contributor.AlternativeAuthor | 명훈 | - |
dc.contributor.AlternativeAuthor | 김명진 | - |
dc.contributor.AlternativeAuthor | 홍성두 | - |
dc.contributor.AlternativeAuthor | 이재일 | - |
dc.contributor.AlternativeAuthor | 임창윤 | - |
dc.identifier.doi | 10.1016/S0304 3835(02)00281-1 | - |
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