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Correlation between high resolution dynamic MR features and prognostic factors in breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Shin Ho | - |
dc.contributor.author | Cho, Nariya | - |
dc.contributor.author | Kim, Seung Ja | - |
dc.contributor.author | Cha, Joo Hee | - |
dc.contributor.author | Cho, Kyung Soo | - |
dc.contributor.author | Ko, Eun Sook | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.date.accessioned | 2010-04-08T23:15:16Z | - |
dc.date.available | 2010-04-08T23:15:16Z | - |
dc.date.issued | 2008-02-07 | - |
dc.identifier.citation | Korean J Radiol 2008;9(1):10-18 | en |
dc.identifier.issn | 1229-6929 (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/62736 | - |
dc.description.abstract | OBJECTIVE: To correlate high resolution dynamic MR features with prognostic factors in breast cancer. MATERIALS AND METHODS: One hundred and ninety-four women with invasive ductal carcinomas underwent dynamic MR imaging using T1-weighted three-dimensional fast low-angle shot (3D-FLASH) sequence within two weeks prior to surgery. Morphological and kinetic MR features were determined based on the breast imaging and reporting data system (BI-RADS) MR imaging lexicon. Histological specimens were analyzed for tumor size, axillary lymph node status, histological grade, expression of estrogen receptor (ER), expression of progesterone receptor (PR), and expression of p53, c-erbB-2, and Ki-67. Correlations between the MR features and prognostic factors were determined using the Pearson chi(2) test, linear-by-linear association, and logistic regression analysis. RESULTS: By multivariate analysis, a spiculated margin was a significant, independent predictor of a lower histological grade (p < 0.001), and lower expression of Ki-67 (p = 0.007). Rim enhancement was significant, independent predictor of a higher histological grade (p < 0.001), negative expression of ER (p = 0.001), negative expression of PR (p < 0.001) and a larger tumor size (p = 0.006). A washout curve may predict a higher level of Ki-67 (p = 0.05). Most of the parameters of the initial enhancement phase cannot predict the status of the prognostic factors. Only the enhancement ratio may predict a larger tumor size (p = 0.05). CONCLUSION: Of the BI-RADS-MR features, a spiculated margin may predict favorable prognosis, whereas rim enhancement or washout may predict unfavorable prognosis of breast cancer. | en |
dc.language.iso | en | en |
dc.publisher | Korean Radiological Society | en |
dc.subject | Breast Neoplasms/*pathology | en |
dc.subject | Carcinoma, Ductal/*pathology | en |
dc.subject | Chi-Square Distribution | en |
dc.subject | Contrast Media | en |
dc.subject | Gadolinium DTPA/diagnostic use | en |
dc.subject | Image Processing, Computer-Assisted | en |
dc.subject | Logistic Models | en |
dc.subject | Magnetic Resonance Imaging/*methods | en |
dc.subject | Neoplasm Invasiveness | en |
dc.subject | Prognosis | en |
dc.subject | Retrospective Studies | en |
dc.title | Correlation between high resolution dynamic MR features and prognostic factors in breast cancer | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이신호 | - |
dc.contributor.AlternativeAuthor | 조나리야 | - |
dc.contributor.AlternativeAuthor | 김승자 | - |
dc.contributor.AlternativeAuthor | 차주희 | - |
dc.contributor.AlternativeAuthor | 조경수 | - |
dc.contributor.AlternativeAuthor | 고은숙 | - |
dc.contributor.AlternativeAuthor | 문우경 | - |
dc.identifier.doi | 10.3348/kjr.2008.9.1.10 | - |
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