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Frequency and predictors of miliary tuberculosis in patients with miliary pulmonary nodules in South Korea: a retrospective cohort study

Cited 5 time in Web of Science Cited 5 time in Scopus
Authors
Jin, Sang-Man; Lee, Hyun Ju; Park, Eun-Ah; Lee, Ho Yun; Lee, Sang-Min; Yang, Seok-Chul; Yoo, Chul-Gyu; Kim, Young Whan; Han, Sung Koo; Shim, Young-Soo; Yim, Jae-Joon
Issue Date
2008-11-28
Publisher
BioMed Central
Citation
BMC Infect Dis 2008, 8:160-166
Keywords
Cohort StudiesKorea/epidemiologyMultiple Pulmonary Nodules/*etiologyMultivariate AnalysisRetrospective StudiesRisk FactorsTuberculosis, Miliary/*complications/diagnosis/*epidemiology/radiographyYoung Adult
Abstract
BACKGROUND: Miliary pulmonary nodules are commonly caused by various infections and cancers. We sought to identify the relative frequencies of various aetiologies and the clinical and radiographic predictors of miliary tuberculosis (TB) in patients with miliary pulmonary nodules. METHODS: We performed a retrospective cohort study of patients who presented with micronodules occupying more than two-thirds of the lung volume, based on computed tomography (CT) of the chest, between November 2001 and April 2007, in a tertiary referral hospital in South Korea. RESULTS: We analyzed 76 patients with miliary pulmonary nodules. Their median age was 52 years and 38 (50%) were males; 18 patients (24%) had a previous or current malignancy and five (7%) had a history of TB. The most common diagnoses of miliary nodules were miliary TB (41 patients, 54%) and miliary metastasis of malignancies (20 patients, 26%). Multivariate analysis revealed that age 25% of total lung volume increased the probability of miliary TB. However, a history of malignancy decreased the probability of miliary TB. CONCLUSION: Miliary TB accounted for approximately half of all causes of miliary pulmonary nodules. Young age, an immune-compromised state, and several clinical and radiographic characteristics increased the probability of miliary TB.
ISSN
1471-2334 (Electronic)
Language
English
URI
http://hdl.handle.net/10371/62757
DOI
https://doi.org/10.1186/1471-2334-8-160
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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