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안압강하제에 의한 전방내 농도의 변한
The Effect of Ocular Hypotensive Agents on the Fluorescein Concentrations in the Antrior Chamber

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Authors
염한수
Issue Date
1962-06
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.3 No.3, pp. 57-61
Abstract
Fluorrescein injected intraveneously appears in the
anterior chamber as green fluorescence easily visible
by the use of slit lamp. The least ampere value of the
slit lamp at the time of its recognition has been used
as the relative concentraton of the fluorescein in the
anterior chamber.
According to the Linner and Fridenwald, the fluorescein
appearance time can be correlated with the rate
of flow of aqueous humor and can be utilized as an
index of aqueous flow. The purpose of this paper is
to study the effects of Diamox and urea on the fluorescein
appearance time and changes in the fluorescein
concentrations in the anterior chamber.
Ten percent solution of sodium fluorescein was injected
intravenously in the ear vein of pigmented
rabbits. the amount of the injection being 0.25ml per
Kg. of body weight. Then. the time interval elapsed
between the end of the injection and appearing in the
pupillry area was determined.
Fifty mg. of Diamox was given orally in one group
of animals and fluoresein solution was injected after
two hours. In another group, one g. of urea per kg.
of body weight was administerd intravenously as a
solution dissolved in 30% invert sugar. and fluorescein
solution was injected after 30 minutes.
For the following 20 minutes. the changes in the
concentrations of fluorescein in the anterior chamber
were determined according to the method of Amsler
and Huber.
In both groups of animals, a marked retardation of
the fluorescein appearance time was noted compared to
normal control group. This late apperance was associated
with the increased time interval between the first
recognition of the dye and its peak concentration in the
anterior chamber. These results are in good agreement
with that of tonographic studies reported by various
authors.
ISSN
0582-6802
Language
Korean
URI
http://hdl.handle.net/10371/6298
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 03 No.3 (1962)
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