실혈후 근조직에 대한 앤티피린 분포

Abstract

Twenty nine female rabbits were bled as much as 1.8% of the body weight. and at from 30 to 50 minutes after bleeding 200 mg of antipyrine was injected intravenousıy. The distribution of antipyrine in the white muscle, red muscle. cardiac muscle. intestinal wall and in the uterine muscle was observed after a definite time elapsed. ranging from 3 to 30 minutes. The curves of distribution ratio. that was the tissue concentration versus plasma concentration. were composed. and they were compared with those obtained in 26 normal unbled rabbits, the control group. On the assumption that the distribution of antipyrine to the tissue is flow limited, the change in the blood flow rate caused from bleeding was examined in individual tissue, and following results were obtained. 1) In the white muscle the time to attain the same concentration with plasma was 14 minutes in the control and 30 minutes in the bled group. In the red muscle it was 11 and 22 minutes, respectively. The delay which was characteristic in the bled group was attributable to the decreased blood flow rate in the tissue. 2) In the cardiac muscle a complete equilibrium between the tissue and plasma was attained by the time of 3 minutes in both groups, and any change of flow rate was not found. 3) There was a unique pattern of distribution in the intestinal wall. A steep rise in the concentration was seen up to 6 minutes, marking 30% above plasma level in the control and 50% in the bled group. Thereafter the distribution ratio decreased gradually and approached to the plasma level by 20 minutes in the control, but in the bled group still revealed 20% above unity after 30 minutes. Thus in the bled group the intestine showed a marked deviation from equilibrium. It was suggested that the mechanism by which antipyrine moves out from the capillary differed from that of inward movement. 4) In the uterine muscle rather similar pattern of distribution with that of the skeletal muscle was observed. The time at which the distribution ratio showed unity was 13 and 30 minutes in the control and in the bled group, respectively, suggesting that the flow rate was lessened in the bled group.