실혈후 근조직에 대한 앤티피린 분포
Distribution of Antipyrine to the Muscle Tissue after Hemorrhage

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Seoul National University College of Medicine
Seoul J Med 1965;6(2):11-19
Twenty nine female rabbits were bled as much as
1.8% of the body weight. and at from 30 to 50 minutes
after bleeding 200 mg of antipyrine was injected intravenousıy.
The distribution of antipyrine in the white
muscle, red muscle. cardiac muscle. intestinal wall and
in the uterine muscle was observed after a definite time
elapsed. ranging from 3 to 30 minutes. The curves of
distribution ratio. that was the tissue concentration versus
plasma concentration. were composed. and they were
compared with those obtained in 26 normal unbled rabbits, the control group.
On the assumption that the distribution of antipyrine
to the tissue is flow limited, the change in the blood
flow rate caused from bleeding was examined in individual
tissue, and following results were obtained.
1) In the white muscle the time to attain the same
concentration with plasma was 14 minutes in the control
and 30 minutes in the bled group.
In the red muscle it was 11 and 22 minutes, respectively.
The delay which was characteristic in the bled
group was attributable to the decreased blood flow rate
in the tissue.
2) In the cardiac muscle a complete equilibrium between
the tissue and plasma was attained by the time
of 3 minutes in both groups, and any change of flow
rate was not found.
3) There was a unique pattern of distribution in the
intestinal wall. A steep rise in the concentration was
seen up to 6 minutes, marking 30% above plasma level
in the control and 50% in the bled group. Thereafter
the distribution ratio decreased gradually and approached
to the plasma level by 20 minutes in the control, but in
the bled group still revealed 20% above unity after
30 minutes. Thus in the bled group the intestine showed
a marked deviation from equilibrium.
It was suggested that the mechanism by which antipyrine
moves out from the capillary differed from that
of inward movement.
4) In the uterine muscle rather similar pattern of distribution
with that of the skeletal muscle was observed.
The time at which the distribution ratio showed unity
was 13 and 30 minutes in the control and in the bled
group, respectively, suggesting that the flow rate was
lessened in the bled group.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 06 No.2 (1965)
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