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Deficit of theory of mind in individuals at ultra-high-risk for schizophrenia

Cited 105 time in Web of Science Cited 113 time in Scopus
Authors
Chung, Yu Sun; Kang, Do-Hyung; Shin, Na Young; Yoo, So Young; Kwon, Jun Soo
Issue Date
2007-12-22
Publisher
Elsevier
Citation
Schizophr Res. 2008 ;99(1-3):111-8.
Keywords
AdolescentAdultCognition Disorders/diagnosis/genetics/psychologyFemaleGenetic Predisposition to Disease/*genetics/psychologyHumansKoreaLongitudinal StudiesMaleMass ScreeningMemory, Short-TermNeuropsychological Tests*Personal Construct TheoryProblem SolvingProspective StudiesRisk FactorsSchizophrenia/diagnosis/*genetics*Schizophrenic PsychologySchizotypal Personality Disorder/diagnosis/*genetics/psychology
Abstract
BACKGROUND: Although a deficit in social cognition is regarded as an early indicator of schizophrenia, few studies have investigated social cognition in ultra-high-risk (UHR) individuals. METHODS: Our investigation involved subjects at UHR for psychosis (N=33) and an age- and IQ-matched healthy control (HC) group (N=36). Two types of theory of mind (ToM) tasks and a neuropsychological test battery were measured. RESULTS: Compared to the HC group, the UHR group performed significantly worse for ToM tasks, with the effect size at an intermediate level (0.64-0.68). Furthermore, the UHR group showed impaired performance in the executive and working memory tests, but not verbal memory tests. These deficits for ToM tests observed in the UHR group were significantly correlated with set-shifting tasks. CONCLUSIONS: Deficits in social cognition may be modest at the prodromal stage of schizophrenia and may be attributed to prefrontal dysfunction. To prevent or delay transition to psychosis, there is a need for specific preventive strategies targeting social functioning for the UHR group.
ISSN
0920-9964 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18096371

http://hdl.handle.net/10371/63311
DOI
https://doi.org/10.1016/j.schres.2007.11.012
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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