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Controlled release of platelet-derived growth factor from porous poly(L-lactide) membranes for guided tissue regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Yoon Jeong | - |
dc.contributor.author | Ku, Young | - |
dc.contributor.author | Chung, Chong Pyoung | - |
dc.contributor.author | Lee, Seung Jin | - |
dc.date.accessioned | 2010-04-30T07:01:40Z | - |
dc.date.available | 2010-04-30T07:01:40Z | - |
dc.date.issued | 1998-02-12 | - |
dc.identifier.citation | Journal of Controlled Release 51 (1998) 201–211 | en |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://hdl.handle.net/10371/63628 | - |
dc.description.abstract | Platelet-derived growth factor-BB (PDGF-BB) was incorporated into porous poly
(L-lactide) (PLLA) membranes with an aim of improving early bone healing in guided tissue regeneration (GTR) therapy. Porous PDGF-BB loaded membranes were fabricated by coating PDGF-BB-dissolved PLLA methylene chloride–ethyl acetate solutions on polyglycolic acid (PGA) meshes. Release kinetics of PDGF-BB, biologic activity, degradability and guided tissue regenerative potentials of the membranes were investigated. Release of PDGF-BB could be controlled by adding bovine serum albumin that may provide porous diffusion channels for PDGF-BB release and by varying initial loading content of PDGF-BB. Biologic activity of PDGF-BB in the membranes was ascertained by fibroblast chemotaxis. PDGF-BB loaded membranes maintained proper degradation property for periodontal application. PDGF-BB loaded membrane markedly increased new bone formation in rat calvarial defects, and completed bony reunion after 2 weeks of implantation period. These results suggested that PDGF-BB loaded PLLA membrane might potentially enhance guided tissue regenerative efficacy. | en |
dc.description.sponsorship | The authors are thankful to Sam Yang Group R and D Center for providing materials. This work was supported by the grant of Korea Science and Engineering Foundation (KOSEF) #94-0403-05-02-3, Korea. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Platelet-derived growth factor | en |
dc.subject | poly (L-lactide) membrane | en |
dc.subject | Controlled release | en |
dc.subject | Guided tissue regeneration | en |
dc.title | Controlled release of platelet-derived growth factor from porous poly(L-lactide) membranes for guided tissue regeneration | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박윤정 | - |
dc.contributor.AlternativeAuthor | 구영 | - |
dc.contributor.AlternativeAuthor | 정종평 | - |
dc.contributor.AlternativeAuthor | 이승진 | - |
dc.identifier.doi | 10.1016/S0168-3659(97)00169-7 | - |
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