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Osteogenic abilities of bone marrow stromal cells are not defective in patients with osteonecrosis
Cited 17 time in
Web of Science
Cited 18 time in Scopus
- Authors
- Issue Date
- 2008-02-20
- Publisher
- Springer Verlag
- Citation
- Int Orthop. 2009 ;33(3):867-72.
- Keywords
- Adult ; Aged ; Alkaline Phosphatase/metabolism ; Bone Marrow Cells/*pathology/physiology ; Calcification, Physiologic/physiology ; Calcium/metabolism ; Cell Proliferation ; Cells, Cultured ; Female ; Femur Head Necrosis/metabolism/*pathology ; Humans ; Male ; Middle Aged ; Osteogenesis/*physiology ; Stromal Cells/pathology/physiology ; Young Adult
- Abstract
- We investigated whether the proliferation activities and osteogenic capacities of bone marrow stromal cells (BMSCs) are depressed in patients with osteonecrosis of the femoral head (ONFH). BMSCs were isolated from fresh bone marrow of the iliac crests of 54 donors and were differentiated into osteogenic lineage in vitro. The results of 27 consecutive patients with ONFH (16 idiopathic and 11 alcohol-induced) were compared with those of 27 patients with a nonnecrotic hip disorder. The proliferative activities of BMSCs in patients with ONFH were not found to be reduced and their osteogenic capacities (alkaline phosphatase activity and calcium deposition amount) were unaltered during in vitro differentiation. Results from patients with idiopathic or alcohol-induced ONFH were similar to those of matched patients with nonnecrotic disorder. These findings suggest that the osteogenic potentials of BMSCs are not defective in patients with ONFH.
- ISSN
- 1432-5195 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18283456
https://hdl.handle.net/10371/63632
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