Predictability of the Test Methods Used in the Detection for Hepatitis B Virus Infection in a Defined Population

Abstract

Predictability for positive (or negativel of the three test protocols (RPHA only; RPHA-PHA; RPHA-PHA-CORABl, which were commonly used in assessing hepatitis B virus (HBVl infection, were evaluated with the reference method of RIA for HBsAg, anti-HBc and anti-HBs in 123 adults in Seoul. RPHA-PHA-CORAB and RPHA-PHA protocols were of great value in estimating prevalence, especially when observed value is obtained from a general population with known sensitivity and specificity indices. Meanwhile, for the purpose of early detection of infection or to select the candidate of vaccination or to select the interviewee to elucidate risk factors of HBV infection, RPHA-PHA-CORAB protocol was the most recommended in detecting HBV infection, because of its high predictability of both positive and negative test results.