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Effect of Osmolality on in vitro Basal and Angiotensin Ⅱ-Stimulated Aldosterone Secretion by Bovine Adrenal Glomerulosa Cells : Osmolality가 소부신 Glomerulosa Cells에서의 기저 및 Angiotension II 자극 알도스테론 분비에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seong Yeon | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Koh, Chang Soon | - |
dc.contributor.author | Min, Hun Ki | - |
dc.date.accessioned | 2009-08-07 | - |
dc.date.available | 2009-08-07 | - |
dc.date.issued | 1988-09 | - |
dc.identifier.citation | Seoul J Med, Vol.29 No.3, pp. 263-270 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6392 | - |
dc.description.abstract | We observed the effect of changes in Na concentration and the associated
changes in the osmolality of incubation media on aldosterone secretion by acutely dispersed isolated bovine glomerulosa cells. We also examined whether this effect is due to changes in Na concentration or to changes in osmolality. When we increased Na concentration and osmolality by addition of NaCl, basal aldosterone secretion was inversely related to the Na concentration and osmolality of the incubation medium. However angiotensin II stimulation increased aldosterone secretion in Low and Normal Na (130 and 149 mM) and osmolality (261 and 297 Osm) media more than in Lower Na (103 mM) and osmolality (210 mOsm) medium. In addition, when osmolality of the medium was increased by addition of NaCI, sucrose and glucose, basal aldosterone secretion was inhibited to a similar extent and increment in aldosterone above basal levels by angiotensin II stimulation was similar, whereas urea addition had no effect. From these results, we conclude that changes in Na concentration affect aldosterone secretion by a mechanism sensitive to the osmolality rather than to the Na concentration. Moreover, since increased osmolality of the incubation medium caused by urea addition has no effect on basal aldosterone levels and increment in aldosterone above basal levels by angiotensin II stimulation, changes in intracellular volume or composition appear to be an important modulator of aldosterone secretion. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Glomerulosa cells | - |
dc.subject | Na concentration | - |
dc.subject | Osmolality | - |
dc.subject | Basal | - |
dc.subject | Angiotensin II (AIl) | - |
dc.subject | Aldosterone | - |
dc.title | Effect of Osmolality on in vitro Basal and Angiotensin Ⅱ-Stimulated Aldosterone Secretion by Bovine Adrenal Glomerulosa Cells | - |
dc.title.alternative | Osmolality가 소부신 Glomerulosa Cells에서의 기저 및 Angiotension II 자극 알도스테론 분비에 미치는 영향 | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 김성연 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.contributor.AlternativeAuthor | 고창순 | - |
dc.contributor.AlternativeAuthor | 민훈기 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 270 | - |
dc.citation.number | 3 | - |
dc.citation.pages | 263-270 | - |
dc.citation.startpage | 263 | - |
dc.citation.volume | 29 | - |
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