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Decreased activity of brush border membrane-bound digestive enzymes in small intestines from pigs experimentally infected with porcine epidemic diarrhea virus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, K. | - |
dc.contributor.author | Ahn, K. | - |
dc.contributor.author | Chae, Chan Hee | - |
dc.date.accessioned | 2009-08-07T02:47:20Z | - |
dc.date.available | 2009-08-07T02:47:20Z | - |
dc.date.issued | 2006-06-08 | - |
dc.identifier.citation | Research in Veterinary Science 81, 310-315 | en |
dc.identifier.issn | 0034-5288 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6471 | - |
dc.description.abstract | Brush border membrane-bound digestive enzymes such as disaccharidases (lactase, sucrase, and maltase), leucine aminopeptidase N, and alkaline phosphatase were measured in jejunum from pigs experimentally infected with porcine epidemic diarrhea virus (PEDV). Three piglets from the infected and control groups were euthanized by electrocution and subjected to necropsy at 24, 36, 48, 60, and 72 hours post-inoculation (hpi). The infection of PEDV to jejunum resulted in significant decreases in brush border membrane-bound digestive enzymes such as disaccharidases (lactase, sucrase, and maltase), leucine aminopeptidase N, and alkaline phosphatase. PEDV replication results in massive destruction of villous enterocytes leading to a marked reduction of intestinal epithelial surface and brush border membrane-bound digestive enzyme activity. Reduced enzymatic activity and villous atrophy in the small intestine is thought to result in a maldigestive and malabsorptive diarrhea. | en |
dc.description.sponsorship | This research was supported by the contract research funds of the Research Institute for Veterinary Science (RIVS) from the College of Veterinary Medicine, Seoul National University, and the Brain Korea 21 Project, Republic of Korea. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Alkaline phosphatase | en |
dc.subject | Disaccharidase | en |
dc.subject | Leucine aminopeptidase N | en |
dc.subject | Pig | en |
dc.subject | Porcine epidemic diarrhea virus | en |
dc.title | Decreased activity of brush border membrane-bound digestive enzymes in small intestines from pigs experimentally infected with porcine epidemic diarrhea virus | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 채찬희 | - |
dc.identifier.doi | 10.1016/j.rvsc.2006.03.005 | - |
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