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Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Sun-A | - |
dc.contributor.author | Park, Jong-Hwan | - |
dc.contributor.author | Seok, Seung-Hyeok | - |
dc.contributor.author | Juhn, Jae-Hyeon | - |
dc.contributor.author | Kim, Seong-Jin | - |
dc.contributor.author | Ji, Hyi-Jeong | - |
dc.contributor.author | Choo, Youn-Sung | - |
dc.contributor.author | Park, Jae Hak | - |
dc.date.accessioned | 2009-08-07T02:47:52Z | - |
dc.date.available | 2009-08-07T02:47:52Z | - |
dc.date.issued | 2006-01-18 | - |
dc.identifier.citation | Experimental and Toxicologic Pathology 2006;57:321–328 | en |
dc.identifier.issn | 0940-2993 | - |
dc.identifier.issn | http://dx.doi.org/10.1016/j.etp.2005.09.006 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6472 | - |
dc.description.abstract | The present study was performed to investigate the protective effects of granulocyte macrophage-colony stimulating factor (GM-CSF) against ulcerative mucositis in hamster buccal pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 μg/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster. | en |
dc.description.sponsorship | This work was supported by LG Life Sciences Ltd. and Brain Korea 21 project. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Mucositis | en |
dc.subject | GM-CSF | en |
dc.subject | 5-FU | en |
dc.subject | Hamster buccal pouch | en |
dc.subject | Immunohistochemistry | en |
dc.title | Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 조선아 | - |
dc.contributor.AlternativeAuthor | 박종환 | - |
dc.contributor.AlternativeAuthor | 석승혁 | - |
dc.contributor.AlternativeAuthor | 전재현 | - |
dc.contributor.AlternativeAuthor | 김성진 | - |
dc.contributor.AlternativeAuthor | 지희정 | - |
dc.contributor.AlternativeAuthor | 추연선 | - |
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