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Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53

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Authors
Ju, Yeun-Jin; Park, Jeong Eun; Juhn, Kyoung Mi; Keong, Jaemin; Yun, Miyong; Park, Myung; Park, Gil-Hong; Choi, Kang-Yell; Cho, Myung-Haing; Wong, Kwok-Kin; Park, Won-Bong; Lee, Kee-Ho
Issue Date
2006
Publisher
Spandidos Publications
Citation
International Journal of Oncology 29: 753-763, 2006
Keywords
chromosomefusionp53radiosensitivitytelomerase
Abstract
and telomerase activation are frequently found in human cancers. p53 inactivation, however, eliminates or attenuates the biological responses to telomerase inhibition and the eventual telomere erosion. We show that telomere erosion can increase the susceptibility to radiation, irrespective of p53 status. Both telomerase inhibition and critically shortened telomere with significant change of chromosomal end-to-end fusion were essential for the enhancement of radiosensitivity. The enhancement was correlated with greater formation of multinucleated cells. p53 inactivation did not eliminate the observed generation of chromosomal fusion and multinucleation, and the resulting increased susceptibility to radiation, as opposed to the previously proved role of p53 in mediating cellular responses to telomere dysfunction. The present findings suggest the importance of chromosomal end fusion in modulating radiosensitivity rather than p53 DNA damage signaling. Thus, the suggested anticancer radiotherapeutic strategy combined with telomerase inhibition could clinically be applicable to cancers, irrespective of p53 status.
ISSN
1019-6439
Language
English
URI
http://www.spandidos-publications.com/ijo/article.jsp?article_id=ijo_29_4_753

http://hdl.handle.net/10371/6482
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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