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Identification of a Peptide Enhancing Mucosal and Systemic Immune Responses against EGFP after Oral Administration in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sae-Hae | - |
dc.contributor.author | Lee, Kyung-Yeol | - |
dc.contributor.author | Kim, Ju | - |
dc.contributor.author | Park, Seung-Moon | - |
dc.contributor.author | Park, BongKyun | - |
dc.contributor.author | Jang, Yong-Suk | - |
dc.date.accessioned | 2009-08-07T03:23:36Z | - |
dc.date.available | 2009-08-07T03:23:36Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Mol. Cells. 21, 244-250 | en |
dc.identifier.issn | 1016-8478 (print) | - |
dc.identifier.issn | 0219-1032 (online) | - |
dc.identifier.uri | http://molcells.inforang.com/about/journal_view.html?uid=405 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6488 | - |
dc.description.abstract | Gangliosides are receptors for various peptides and
proteins including neuropeptides, β-amyloid proteins, and prions. Recently, the role of gangliosides in mucosal immunization has attracted attention due to the emerging interest in oral vaccination. Ganglioside GM1 exists in abundance on the surface of the M cells of Peyers patch, a well-known mucosal immunity induction site. In the present study we identified a peptide ligand for GM1 and tested whether it played a role in immune induction. GM1-binding peptides were selected from a phage-displayed dodecapeptide library and one peptide motif, GWKERLSSWNRF, was fused to the C-terminus of enhanced green fluorescent protein (EGFP). The fusion protein, but not EGFP fused with a control peptide, was concentrated around Peyers patch after incubation in the lumen of the intestine ex vivo. Furthermore, oral feeding of the fusion protein but not control EGFP induced mucosal and systemic immune responses against EGFP resembling Th2-type immune responses. | en |
dc.description.sponsorship | This work was supported by a Korean Research
Foundation Grant (KRF-2002-070-C00069) and, in part, by a grant from the Plant Diversity Research Center of the 21st Century Frontier Research Program (PF0330301-00) funded by the Ministry of Science and Technology of Korea. | en |
dc.language.iso | en | - |
dc.publisher | 한국분자·세포생물학회 = Korean Society of Molecular and Cellular Biology | en |
dc.subject | Adjuvant | en |
dc.subject | Ganglioside | en |
dc.subject | Mucosal Immunization | en |
dc.subject | Phage Display Library | en |
dc.title | Identification of a Peptide Enhancing Mucosal and Systemic Immune Responses against EGFP after Oral Administration in Mice | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김새해 | - |
dc.contributor.AlternativeAuthor | 이경열 | - |
dc.contributor.AlternativeAuthor | 김주 | - |
dc.contributor.AlternativeAuthor | 박승문 | - |
dc.contributor.AlternativeAuthor | 박봉균 | - |
dc.contributor.AlternativeAuthor | 장용석 | - |
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