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Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Aruoma, Okezie I. | - |
dc.contributor.author | Sun, Buxiang | - |
dc.contributor.author | Fujii, Hajime | - |
dc.contributor.author | Neergheen, Vidushi S. | - |
dc.contributor.author | Bahorun, Theeshan | - |
dc.contributor.author | Kang, Kyung-Sun | - |
dc.contributor.author | Sung, Mi-Kyung | - |
dc.date.accessioned | 2009-08-07T05:20:25Z | - |
dc.date.available | 2009-08-07T05:20:25Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | BioFactors 27 (2006), 245-265 | en |
dc.identifier.issn | 0951-6433 (print) | - |
dc.identifier.issn | 1872-8081 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/6508 | - |
dc.description.abstract | Interdisciplinary research endeavors are directed at understanding the molecular mechanisms of neurodegenerative and chronic diseases that affect human lifestyle. Hence the potential for developing medicinal herb-derived and food plant-derived prophylactic agents directed at neurological, metabolic, cardiovascular and psychiatric disorders abounds. Oligonol is a novel technology product emanating from the oligomerization of polyphenols, typically proanthocyanidin from a variety of fruits (grapes, apples, persimmons etc.) that has optimized bioavailability. It is an optimized phenolic product containing catechin-type monomers and oligomeric proanthocyanidins, the easily absorbed forms. Typically the constituents of Oligonol are 15-20% monomers, 8-12% dimers and 5-10% trimers. Supplementation of mice with Oligonol prior to the administration of ferric-nitrilotriacetic complex (a Fenton chemistry model) significantly reduced the extent of lipid peroxidation in the kidney, brain and liver. Oligonol triggers apoptosis in the MCF-7 and MDA-MB-231 breast cancer cells through modulation of the pro-apoptotic Bcl-2 family of proteins and the MEK/ERK signaling pathway, an observation suggesting its important chemopreventive effects. The senescence-accelerated strain of mice (SAM) are models of senescence acceleration and geriatric disorders which exhibit learning and memory deficits and enhanced production or defective control of oxidative stress leading. | en |
dc.description.sponsorship | The authors are grateful to Mr. Ken-ichi Kosuna of Amino Chemical Company for his foresight in
the development of functional biotechnology products of prophylactic importance in the management of health and chronic diseases. Okezie I Aruoma is Adjunct Research Professor, at the University of Mauritius. | en |
dc.language.iso | en | - |
dc.publisher | Wiley-Blackwell | en |
dc.publisher | International Union of Biochemistry and Molecular Biology | - |
dc.subject | Oligonol | en |
dc.subject | neurodegenerative diseases | en |
dc.subject | anti-aging prophylactic agent | en |
dc.subject | metabolic disorders | en |
dc.subject | functional foods | en |
dc.subject | Age-dependent disorders | en |
dc.subject | flavonoids | en |
dc.subject | redox biochemistry | en |
dc.subject | inflammation and cell signaling | en |
dc.subject | chemoprevention | en |
dc.subject | neuroprotection | en |
dc.title | Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 강경선 | - |
dc.contributor.AlternativeAuthor | 성미경 | - |
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