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Molecular analysis of duck hepatitis virus type 1 reveals a novel lineage close to the genus Parechovirus in the family Picornaviridae

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Authors
Kim, Min-Chul; Kwon, Yong-Kuk; Joh, Seong-Joon; Lindberg, A. Michael; Kwon, Jun-Hun; Kim, Jae-Hong; Kim, Sun-Joong
Issue Date
2006
Publisher
Society for General Microbiology
Citation
J Gen Virol 87, 3307–3316
Abstract
Duck hepatitis virus type 1 (DHV-1) was previously classified as an enterovirus, based primarily
on observed morphology and physicochemical properties of the virion. The complete nucleotide
sequences of two strains (DRL-62 and R85952) of DHV-1 have been determined. Excluding
the poly(A) tail, the genomes are 7691 and 7690 nt, respectively, and contain a single, large
open reading frame encoding a polyprotein of 2249 aa. The genome of DHV-1 is organized as
are those of members of the family Picornaviridae: 59 untranslated region (UTR)–VP0–VP3–
VP1–2A1–2A2–2B–2C–3A–3B–3C–3D–39 UTR. Analysis of the genomic and predicted
polyprotein sequences revealed several unusual features, including the absence of a predicted
maturation cleavage of VP0, the presence of two unrelated 2A protein motifs and a 39 UTR extended
markedly compared with that of any other picornavirus. The 2A1 protein motif is related to the
2A protein type of the genus Aphthovirus and the adjacent 2A2 protein is related to the 2A protein
type present in the genus Parechovirus. Phylogenetic analysis using the 3D protein sequence
shows that the two DHV-1 strains are related more closely to members of the genus Parechovirus
than to other picornaviruses. However, the two DHV-1 strains form a monophyletic group,
clearly distinct from members of the genus Parechovirus.
ISSN
0022-1317
Language
English
URI
http://hdl.handle.net/10371/6528
DOI
https://doi.org/10.1099/vir.0.81804-0
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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