SHERP

Effect of Corticosterone on the Serotonin Receptor Binding Properties in Rat Cerebral Cortex
Corticosterone이 흰쥐 대뇌피질 serotonin 수용체 결합성에 미치는 영향에 관한 연구

Cited 0 time in webofscience Cited 0 time in scopus
Authors
Park, Sung Woo; Suh, Yoo Hun; Woo, Jong Inn; Park, Chan-Woong
Issue Date
1987-12
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1987;28(4):303-309
Keywords
Serotonin receptorCorticosteroneRat brainAdrenalectomy
Abstract
A possible role of brain serotonin in the regulation of HPA axis activity including
feed-back sensitivity has been studied by many investigators.
The present study was undertaken to check the serotonin binding to rat cerebral cortex
membrane before and after corticosterone replacement in adrenalectomized rats.
Both the affinity and the number of serotonin binding sites were significantly increased
following corticosterone replacement, compared to those of adrenalectomized control.
In conclusion, the present study strongly suggests that cerebral cortical serotonin receptor
sensitivity might be changed by repeated treatment with corticosterone and may support the
assumption of serotoninergic regulation in feed-back activity of HPA axis.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/6553
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.4 (1987)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse