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Effect of Ketamine on the Acetylcholine Concentration of Various Regions of Rat Brain
Ketamine이 백서뇌 부위별 Acetylcholine 함량에 미치는 영향

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Authors
Hong, Chong Hwa; Woo, Jong Inn; Suh, Yoo Hun; Park, Chan-Woong; Lee, Chung Kyoon
Issue Date
1987-12
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1987;28(4):347-351
Keywords
AcetylcholineRat brainBehavior
Abstract
After Ketamine administration (30 mg/kg, intraperitoneally), acetylcholine (ACh)
concentrations did not change significantly at 10 min, but started to decrease in several brain
regions at 30 min, .ind decreased markedly in all regions at 60 min. ACh levels returned to
almost normal after 4 hrs. The decrease was most marked in pons-medulla, cerebral cortex,
hippocampus, and corpus striatum. In these regions, a dose (5 mg/kg, intraperitoneally) far
below the anesthetic doses decreased ACh levels as much as 30 mg/kg. The derease in ACh
levels induced by ketamine may be associated with hallucination, delirium, dream, amnesia,
and analgesia which occur in humans at subanesthetic doses of ketamine and during recovery
from ketamine anesthesia.
Key words: Ketamine. Acetylcholine
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/6558
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.4 (1987)
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