항암제 Busulfan이 백서태자에 미치는 영향

Abstract

Sprague-Dawley strain rats evere administered orally three times with the doses of Busulfan 5mg/kg body weight, 10mg/kg body weight and 15mg/kg body weight on the 6th 8th 10th day of gestation, 7th 9th 11th day of gestation and 9th 11th 13th day of gestation respectively. Gross anomalies in the fetuses, weight, length and breadth. of the brain of the live fetusee, survival rate of fetuses, changes of fetal body weight and numbers of corpus luteum of maternal ovaries were studied after hysterectomy on the 22nd day of gestation and the following results were obtained. 1. Most obvious decrease of the survival rate was observed in the group of 15mg/kg body weight. Gradual decrease of survival rate was in inverse accordance with days of gestation. 2. Significant changes of fetal body weight came out in the results of all groups treated with the administration of the Busulfan, and in the earlier administration groups, the more obvious decrease of the fetal body weight were observed. 3. Gradual decrease of the weight of the brain appeared in all treated groups in accordance with the doses administered, and most notable decrease resulted in the group which was administered with the dose of 15mg/kg body weight. 4. Obvious reduction of the length of the fetal brain took place in an groups. And the results were in proportion to the doses. 5. Gradual reduction of the breadth of the fetal brain was observed in proportion to the doses and according to the period of gestation treated with Busulfan. 5. The gross anomalies were appeared in all treated groups, and those were short tail, growth retardation, microcephalus. hydrocephalus, micromelia, abnormal number of digits, syndactili and edema. The abnormal tails were observed in the highest incidence throughout the anomalies appeared in the fetuses of experimental groups. Combined anomalies of micromelia, syndactylia and edema were characteristic. 7. Number of the corpus luteum was not effected by the administration of the Busulfan.