히스타민이 장운동성에 미치는 영향

Abstract

The effect of histamine on the motility was investigated in the isolated ileum of rabbit. The longitudinal tension of muscle strips in Ringer-Tyrode's and 1 p.g/ ml histamine solution was recorded on a physiograph by way of the force transducer (Narco Biosystem, Model B). Atropine or diphenhydramine was used as a companion drug. The motility was represented by the magnitude of impulse which was obtained from the area beneath tension curve and contraction frequency which was counted by the number of rhythmic waves on recor< ling paper. The results obtained were as follows: 1. The motility of the rabbit ileum increased in J'g/ml histamine solution. The effect of histamine on the motility of the muscle strip was blocked by diphenhydramine. but not by atropine. 2. The motility of the isolated rabbit ileum was not influenced by atropine. 3. The motility of the isolated ileum decreased in 1 p.g/ml diphenhydramine. It was inferred that rabbit ileum might contract with histamine and relax with diphenhydramine by their direct effects.