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망간 이온이 개구리 심방근의 막전압 및 수축력에 미치는 영향
Effects of Manganese Ion on the Action Potential and Contractility of Frog Atrial Muscle

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Authors
엄융의; 김전; 엄대용; 김기환; 남기용
Issue Date
1977-03
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.18 No.1, pp. 37-43
Abstract
The effect of manganese ion on transmembrane
potential and tension of the atrial strip was studied in
the frog. Manganese (l~8 mM) suppressed the plateau
resulting in a shortening of action potential
duration. The change was a function of time and
during the first 5 minutes the action potential duration
increased, then it gradually shortened. Although
resting membrane was more or less hyperpolarized,
there was no significant changes in the amplitnde of
action potential and resulted in an increased overshoot
potential. In all the experiments the contractile tension
of atrial muscle superfused with Mn-Ringer decreased
consistently as the concentration of manganese
increased. But 10 to 20% of relative tension to that
of control persisted even at 8 mM Mn-Ringer for more
than half an hour. Manganese elevated the threshold
of atrial contraction and reduced the conduction velocity.
The above results suggested that manganese not
only altered the transmembrane potential but also
acted on the excitation-contraction coupling to produce
a decrease in tension.
ISSN
0582-6802
Language
Korean
URI
http://hdl.handle.net/10371/6621
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 18 No.1 (1977)
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