집먼지진드기 과민성 호흡기 알레르기의 면역 요법에 대한 임상적 관찰

Abstract

House dust mite (HDM) as a major antigen in the house dust is one of the most important offending allergens in bronchial asthma and allergic rhinitis. In Korea, Cho et al. found Dermatophagoldes farinae(53.6%) and D. pteronyssinus in house dust, which are the main species of house dust mites responsible for respiratory allergy in many countries (1977). Kang et al. reported that 26% of respiratory allergic patient in Korea have positive skin reaction to the extract of D. pteronyssinus in prick test (1979). Because the avoidance of house dust mites is practically impossible, the hyposensitization treatment (immunotherapy) may be the only effective radical treatment. To evaluate the efficacy of the hyposensitization treatment in HDM sensitized respiratory allergies, we tried it to 35 patients (18 bronchiala sthma patients, 8 allergic rhinitis patients and 9 combined cases) with a tyrosine-adsorbed glycerinated extract of D. pteronyssinus, and the following results were obtained. L As a whole, the efficacy of the treatment was substantial in 10 patients (28.6%) and fair in 17 patients (48.6%), so about 77% of the studied subjects had significant symptomatic reliefs. 2. In relation to the disease entity, the efficacy of the treatment was substantial in 6 of 18 bronchial asthma patients and 2 of allergic rhinitis patients. 3. The shorter the duration of the disease is, the more excellent the efficacy of treatment resulted. If the duration less than 1 year, 40% of the patients had substantial effect and if it was more than 11 years, no patients got such effect. 4. Almost all of the patients with substantial effect are below 30 years of age, indicating better effect in younger age. 5. Seasonal relationship of the symptom & sex difference had no significant relationship with the efficacy of the treatment.