여성 배난 주기중 뇨 Estrone-3a-glucuronide와 Pregnanediol-3a-glucuronide의 농도변화

Abstract

To assess the reliability of monitoring overian function and fertile period, the concentrations of urinary LH, estrone-3a-glucuronide CE,-G) and pregnanediol3a- glucuronideCP'diol-G) were measured by direct radioimmunoassay on unextracted daily samples of early morning urine throughout the 6 consecutive ovarian cycles of 14 Korean women. The changes in levels of urinary E,-G, P'diol-G and E,-G/P'diol-G ratio during ovarian cycle, the intra-individual variations, and the suitability of various mathematical indices for predicting the start and finishing of the fertile period were observed. The results have shown that the measurement of E,-G and P'diol-G in early morning urine may be of value for monitoring follicular development and luteal function in women over long periods of time without the problems of stress and inconvenience to the patients. The most feasible indices for predicting the start and finishing of the fertile period were obtained in urinary E,-G and E,-G/P'diol-G ratio respectively. This study was supported by World Health Organization.