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Microtubuloreticular Structures in Autoimmune-related Myopathy
자가면역성 근병증에서의 Microtubuloreticular structure (MTRS)

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Authors
Kwon, Tae Jung; Park, Sung Hye; Chi, Je G.
Issue Date
1991-09
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1991;32(3):121-129
Keywords
Microtubuloreticular structureInflammatory myopathyEndothelial cellPericyteFibroblastDermatomyositisAutoimmune disease
Abstract
Microtubuloreticular structures are composed of undulating reticulated microtubules
lying within dilated cisternae of rough endoplasmic reticulum, measuring
18-27 nm in diameter. Although these structures occasionally occur in normal mammalian
cells, most examples come from the tissues of diseased individuals, particularly
from cases of autoimmune disease and viral infection. We have experienced 10 cases
of inflammatory myopathy in the last 2 years. Of particular interest was their presence
in the pericytes (3 cases), stromal fibroblasts (2 cases) and histiocytes (1 case) as well
as in the endothelial cells in 8 cases. Two cases of polymyositis revealed a marked
degenerative change without evident microtubuloreticular structures in the capillary
endothelial cells. These findings confirm the previous reports that these structures are
of considerable diagnostic value for autoimmune-related myopathy when taken in conjunction
with other clinicopathological features, and also prove that the pericyte should
be included as the target cell of microtubuloreticular structures.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/6745
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 32 No.3 (1991)
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