Publications
Detailed Information
Bioavailability of Oral Prednisolone : Prednisolone 정제의 생체이용률
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyeong-Hun | - |
dc.date.accessioned | 2009-08-10T03:07:40Z | - |
dc.date.available | 2009-08-10T03:07:40Z | - |
dc.date.issued | 1991-09 | - |
dc.identifier.citation | Seoul J Med, Vol.32 No.3, pp. 131-137 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6746 | - |
dc.description.abstract | To assess the bioavailability of a oral prednisolone preparation, prednisolone
crossover pharmacokinetics were studied in eight healthy male volunteers following intravenous infusion of prednisolone sodium phosphate 81 mg (equivalent to prednisolone 60 mg) solution over a period of 5 minutes, and oral administration (60 mg) of prednisolone tablets. On two study days, 3 weeks apart, 8 healthy subjects received two prednisolone preparations in random order. Plasma samples were collected over a 24 hr study period and analyzed for prednisolone concentration by high-pressure liquid chromatography, and protein binding was assessed using equilibrium dialysis at 37°C. Oral data demonstrated a time to peak concentration of 2.3 ± 0.5 hours (SD), mean residence time of 5.6 ± 0.5 hours, and absolute bioavailability (oral/i.v.) of 58.5 ± 12.2%. The estimated terminal half-life was 3.0 ± 0.4 hours, the total body clearance was 10.9 ± 3.5 L/hr. Infusion data demonstrated a significantly (P <0.05) shorter mean residence time, 3.4 ± 0.4 hours, with no significant difference in terminal half-life, 2.7 ± 0.3 hours, and total body clearance 12.1 ± 2.1 L/hr. With respect to free prednisolone, oral data demonstrated a significantly (P <0.01) longer mean residence time than that of infusion data, and AUC ratio (AUCoTal / AUe.v.) was 0.667 ± 0.091. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Prednisolone | - |
dc.subject | Bioavailability | - |
dc.subject | Pharmacokinetics | - |
dc.title | Bioavailability of Oral Prednisolone | - |
dc.title.alternative | Prednisolone 정제의 생체이용률 | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 이경훈 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 137 | - |
dc.citation.number | 3 | - |
dc.citation.pages | 131-137 | - |
dc.citation.startpage | 131 | - |
dc.citation.volume | 32 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.