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Esco2 is a novel corepressor that associates with various chromatin modifying enzymes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Beom-Jun | - |
dc.contributor.author | Kang, Kyung-Min | - |
dc.contributor.author | Jung, Sung Yun | - |
dc.contributor.author | Choi, Hyun-Kyung | - |
dc.contributor.author | Seo, Jong-Hun | - |
dc.contributor.author | Chae, Ji-Hye | - |
dc.contributor.author | Cho, Eun-Jung | - |
dc.contributor.author | Youn, Hong-Duk | - |
dc.contributor.author | Qin, Jun | - |
dc.contributor.author | Kim, Seong-Tae | - |
dc.date.accessioned | 2010-06-07T01:05:12Z | - |
dc.date.available | 2010-06-07T01:05:12Z | - |
dc.date.issued | 2008-05-27 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications 372 (2008) 298-304 | en |
dc.identifier.issn | 1090-2104 (Electronic) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBK-4SJPVWR-5-9&_cdi=6713&_user=168665&_orig=search&_coverDate=07%2F25%2F2008&_sk=996279997&view=c&wchp=dGLzVzz-zSkWz&md5=0dc16d2e48022a21418f525a06b78de9&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67484 | - |
dc.description.abstract | Accurate chromosome segregation during cell division requires that sister chromatids are kept together by cohesin complex until anaphase, when the chromatids separate and distribute to the two daughter cells. Esco2 is an acetyltransferase that is required for the establishment of sister chromatid cohesion during S phase. Here, we report that Esco2 interacts with several component proteins of the CoREST complex, including a transcription corepressor CoREST, histone demethlyase LSD1, HDAC1, HDAC2, BRAF35, and PHF21A. Esco2 also interacts with various histone methyltransferases Suv39h1, SETDB1 and G9a. Esco2 complex purified from HeLa nuclear extract possesses histone H3 K9 methylation activity and functions as a transcription repressor. Esco2 fused to Gal4 DNA binding domain represses transcription by increasing methylation of histone H3 K9 in the promoter region. These results suggest a novel function of Esco2 in transcription repression through modulation of the chromatin structure. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Acetyltransferases/genetics/*metabolism | en |
dc.subject | Cell Line | en |
dc.subject | Chromatin/*enzymology | en |
dc.subject | Chromosomal Proteins, Non-Histone/genetics/*metabolism | en |
dc.subject | Hela Cells | en |
dc.subject | Histone-Lysine N-Methyltransferase/genetics/*metabolism | en |
dc.subject | Histones/metabolism | en |
dc.subject | Humans | en |
dc.subject | Methyltransferases/metabolism | en |
dc.subject | Protein Methyltransferases/metabolism | en |
dc.subject | Repressor Proteins/genetics/*metabolism | en |
dc.subject | Transcription, Genetic | - |
dc.title | Esco2 is a novel corepressor that associates with various chromatin modifying enzymes | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김범준 | - |
dc.contributor.AlternativeAuthor | 강경민 | - |
dc.contributor.AlternativeAuthor | 정성윤 | - |
dc.contributor.AlternativeAuthor | 최현경 | - |
dc.contributor.AlternativeAuthor | 서종헌 | - |
dc.contributor.AlternativeAuthor | 채지혜 | - |
dc.contributor.AlternativeAuthor | 조은정 | - |
dc.contributor.AlternativeAuthor | 윤홍덕 | - |
dc.contributor.AlternativeAuthor | 김성태 | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.05.056 | - |
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