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Effects of Higenamine on the Contractility of Aorta and Taenia Coli in Guinea-piqs : Higenamine이 기니피그 대동맥 및 결장뉴 평활근의 수축성에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | Suk, Sang Bok | - |
dc.contributor.author | Ko, Kwang Wook | - |
dc.contributor.author | Lee, Sang Jin | - |
dc.contributor.author | Hwang, Sang-Ik | - |
dc.contributor.author | Kim, Ki-Whan | - |
dc.date.accessioned | 2009-08-10T03:35:15Z | - |
dc.date.available | 2009-08-10T03:35:15Z | - |
dc.date.issued | 1991-12 | - |
dc.identifier.citation | Seoul J Med, Vol.32 No.4, pp. 223-238 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6760 | - |
dc.description.abstract | Higenamine isolated from Aconiti tuber is known to have positive inotropic
action through the adrenergic ~-receptors. However, the effects of higenamine on the vascular smooth muscle and taenia coli have not yet been elucidated. The actions of higenamine were investigated on the activated aortic strips of guinea-pigs and rabbits by norepinephrine, high K-Tyrode's solution and electrical field stimulation, and also on the spontaneous contractions of guinea-pig taenia coli. Electrical activities and mechanical contractions were simultaneously recorded using the conventional suction-electrode method and single sucrose gap technique. All experiments were performed in tris-buffered Tyrode's solution which was aerated with 100% O2 and kept at 35°C. Higenamine suppressed dose-dependently the norepinephrine-induced contraction. Propranolol potently antagonized the inhibitory effects of higenamine on rabbit aorta, while less potently on guinea-pig aorta. Higenamine seemed to suppress profoundly the component of intracellular Ca2+ mobilization in the contraction curve of norepinephrine in guinea-pig aorta. Higenamine did not seem to suppress the component of Ca2 + influx through the potential-sensitive Ca2 + channel in K-contracture of guinea-pig aorta. Higenamine suppressed both passive resting tension and active tension (phasic contraction) driven by electrical field stimulation (A.C. 60 Hz, 5-7 V/cm, duration 10 sec, interval 3 min) in guinea-pig aorta. Propranolol also rapidly suppressed both passive resting and active tensions. Higenamine dose-dependently suppressed the frequency and amplitude of spontaneous contraction, resulting in complete abolishment of it above 10-6 M concentration in guinea-pig taenia coli. Propranolol almost completely antagonized its effect. Higenamine reduced dose-dependently both burst frequency and spike frequency, and depolarized membrane potential in guinea-pig taenia coli. Propranolol almost completely blocked its effect. In conclusion the inhibitory action of higenamine to the norepinephrine-induced contraction might be produced by the depression of intracellular Ca2+ mobilization and Ca2+-influx through ~-adrenoceptors in guinea-pig aorta. The Ca2+-influx through the potential-sensitive Ca2+ channel might not be suppressed by higenamine in guinea-pig aorta. The inhibitory effects of higenamine on the spontaneous contractions of guineapig taenia coli result from the decrease of burst frequency and spike frequency through the ~-adrenoceptors. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Higenamine | - |
dc.subject | Aorta | - |
dc.subject | Taenia coli | - |
dc.subject | Norepinephrine-induced contraction | - |
dc.subject | Electrical field stimulation | - |
dc.subject | K-contracture | - |
dc.subject | Spontaneous contraction | - |
dc.title | Effects of Higenamine on the Contractility of Aorta and Taenia Coli in Guinea-piqs | - |
dc.title.alternative | Higenamine이 기니피그 대동맥 및 결장뉴 평활근의 수축성에 미치는 영향 | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 석상복 | - |
dc.contributor.AlternativeAuthor | 고광욱 | - |
dc.contributor.AlternativeAuthor | 이상진 | - |
dc.contributor.AlternativeAuthor | 황상익 | - |
dc.contributor.AlternativeAuthor | 김기환 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 238 | - |
dc.citation.number | 4 | - |
dc.citation.pages | 223-238 | - |
dc.citation.startpage | 223 | - |
dc.citation.volume | 32 | - |
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