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Protective effects of ethyl pyruvate treatment on paraquat-intoxicated rats

Cited 45 time in Web of Science Cited 30 time in Scopus
Authors
Lee, JH; Kwon, WY; Jo, YH; Suh, GJ; Youn, YK
Issue Date
2008-05-16
Publisher
SAGE Publications
Citation
Hum Exp Toxicol. 2008; 27(1): 49-54
Keywords
Animals*Anti-Inflammatory Agents, Non-Steroidal*AntioxidantsGlutathione/metabolismHerbicides/*poisoningInterleukin-6/metabolismLipid Peroxidation/drug effectsLiver/metabolismLung/drug effects/metabolism/pathologyMaleMalondialdehyde/metabolismNitrates/metabolismNitric Oxide/metabolismNitrites/metabolismParaquat/*poisoningPyruvates/*therapeutic useRatsRats, Sprague-Dawley
Abstract
Although, numerous studies have attempted to reduce the oxygen radical injury induced by the antioxidants in paraquat intoxication, these antioxidant therapies have showed few survival benefits. Ethyl pyruvate (EP) may function as an effective scavenger of oxygen radicals, an anti-inflammatory agent and an energy source in many ischemia reperfusion models. The aim of this study was to evaluate the antioxidant and anti-inflammatory effects of EP on the lung and the liver tissues in paraquat-intoxicated rats. Rats were randomly given either a low (2 mg/kg i.p.) or high (40 mg/kg i.p.) EP dose, 30 min before or 1 h after paraquat (50 mg/kg i.p.) administration, and subsequently killed at 6 and 24 h. Glutathione (GSH) and malondialdehyde (MDA) levels of the lungs and the livers, and plasma nitric oxide (NO) concentrations were measured. Pretreatment of EP significantly decreased the MDA level in the lung and the liver tissues. EP also significantly decreased plasma NO concentrations at 6 h. EP pretreatment, however, failed to show significant change in GSH concentration. In post-treatment of EP, MDA levels in the lung tissue and plasma NO levels were significantly decreased. In conclusion, EP decreased the lipid peroxidation and seemed to exert an anti-inflammatory action in the paraquat intoxication rat model.
ISSN
0960-3271 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18480149

http://het.sagepub.com/cgi/reprint/27/1/49.pdf

http://hdl.handle.net/10371/67777
DOI
https://doi.org/10.1177/0960327108088976
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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