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Hyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patients

Cited 23 time in Web of Science Cited 23 time in Scopus
Authors
Choe, Yon Ho; Jin, Dong-Kyu; Kim, Sang Eun; Song, Sang Yong; Paik, Kyung Hoon; Park, Hwa Young; Oh, Yoo Joung; Kim, An Hee; Kim, Jung Sim; Kim, Chi Wha; Chu, Su-Hyun; Kwon, Eun Kyung; Lee, Kyung Han
Issue Date
2005-01-20
Publisher
Endocrine Society
Citation
J Clin Endocrinol Metab. 90(6):3367-3370
Keywords
AdolescentBody HeightBody WeightChildFemaleGastric Emptying/*physiologyGhrelinHumansMalePeptide Hormones/*bloodPrader-Willi Syndrome/*blood/*physiopathologyReference Values
Abstract
Prader-Willi syndrome (PWS) is the most common form of syndromic obesity associated with hyperphagia. Because ghrelin stimulates gastric motility in rodents, and PWS patients have 3- to 4-fold higher fasting plasma ghrelin concentrations than normal subjects, we hypothesized that hyperphagia associated with PWS may be partly explained by rapid gastric emptying due to the increased gastric motility caused by ghrelin. We determined gastric emptying times (GETs) and measured ghrelin levels in 11 PWS children and 11 age-, sex-, and body mass index-matched controls using a standard meal containing [(99m)Tc]diaminetriaminepentacetate. Median plasma ghrelin levels before (precibum) and after the GET study were higher in PWS patients than in controls (P = 0.004 and P = 0.001, respectively). Median percent gastric retentions at 90 min after the standard meal were 57.1% (range, 34.0-83.2%) in PWS patients and 40.2% (range, 27.2-60.2%) in controls (P = 0.03). In particular, precibum ghrelin concentrations were not significantly correlated with the rate of gastric emptying in PWS patients (P = 0.153; r = 0.461) or controls (P = 0.911; r = 0.048). Our results show that gastric emptying in PWS is reduced despite higher ghrelin levels, and that the voracious appetite associated with PWS is related to another mechanism.
ISSN
0021-972X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15657368

http://hdl.handle.net/10371/67817
DOI
https://doi.org/10.1210/jc.2004-1651
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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